نتایج جستجو برای: janus kinase 2
تعداد نتایج: 2686970 فیلتر نتایج به سال:
Biatractylolide is an Atractylodes macrocephala derived bisesquiterpenoid that has been found treatment of dementia in model mice. This study aims to explore the therapeutic effect on vascular dementia. Network pharmacological techniques have used elaborate involved mechanisms biatractylolide treating Based PubChem database, Swiss target prediction and human gene database GeneCards, 19 common m...
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and drug resistance. INCB16562 was developed as a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. The specific cellular...
Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes patients seek efficient therapies to achieve sustained remissions. The complex nature greatly complicates patients’ responses appropriate treatments. Objectives: This review was conducted focus on Janus kinase (JAK) pathway, evaluate its role as ne...
Tofacitinib, ein Janus-Kinase (JAK)-Inhibitor, ist eine wichtige Therapieoption für RA-Patienten mit hoher Krankheitsaktivität. In den letzten Jahren es zu Sicherheitsbedenken im Zusammenhang dem Auftreten venöser Thromboembolien bei Behandlung JAK-Inhibitoren gekommen. Desai et al. kamen nun Erkenntnissen über das Risiko venöse Rahmen einer Tofacitinib-Behandlung RA-Patienten.
Polymorphonuclear neutrophils (PMN) are phagocytic cells constitutively programmed for apoptotic cell death. Exposure to GM-CSF delays apoptosis as measured by annexin-V staining and cell morphological change. We found that STAT5B, STAT1, and STAT3 DNA-binding activity was induced by GM-CSF. We also detected activation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway after GM-CSF trea...
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...
CGP 57148 is a potent inhibitor of the ABL protein tyrosine kinase and a promising new compound for the treatment of a variety of BCR-ABL-positive leukemias. We used this enzyme inhibitor to characterize the biological effects of BCR-ABL in primary cells and two growth factor-dependent BCR-ABL-transfected cell lines. The effect of CGP 57148 on primary cells is dependent on the stage of differen...
Cellular responses to dozens of cytokines and growth factors are mediated by the evolutionarily conserved Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway (Fig. 1). These responses include proliferation, differentiation, migration, apoptosis, and cell survival, depending on the signal, tissue, and cellular context. JAK/STATsignaling is essential for n...
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