Human diseases are inherently complex and governed by the complicated interplay of several underlying factors. Clinical research focuses on behavioral, demographic and pathology information, whereas molecular genomics focuses on finding underlying genetic and genomic factors in genomic data collected on mRNA expression, proteomics, biological networks, and other microbiological features. Howeve...

HomeCirculation: Cardiovascular ImagingVol. 14, No. 4Impaired Right Ventricular Longitudinal Strain Without Pulmonary Hypertension in Patients Who Have Recovered From COVID-19 Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBImpaired Vincen...

•DPF-3, a DPPIV family protease, protects C. elegans fertility•Loss of DPF-3 alters cellular endo-siRNA profiles and desilences transposons•DPF-3-mediated processing WAGO-1/-3 Argonaute proteins promotes siRNA sorting•A combination processing-refractive WAGO-1 WAGO-3 phenocopies loss Small RNA pathways defend the germlines animals against selfish genetic elements, yet pathway activities need to...

An important task for evolutionary biology is to explain how phenotypes change over evolutionary time. Neo-Darwinian theory explains phenotypic change as the outcome of genetic change brought about by natural selection. In the neo-Darwinian account, genetic change is primary; phenotypic change is a secondary outcome that is often given no explicit consideration at all. In this article, we intro...

Errant authors of empirical learning reports are often dashed to earth by editorial reviewers, who castigate them for trivial departures from the orthodox associative paradigms subserving a vacuous general-process notion, which allows no consideration of specialized structures in humans or in beasts. Paradigmatic illustrations of immediate reinforcement were not subjected to the same zealous sc...

An isolated strain (from rice), Bacillus acidocaldarius was able to produce extracellular α-amylase.The enzyme was partially purified with 50% acetone and showed 4.3-fold purification. Amylase was immobilized on different carriers by different methods and its specific activity for starch hydrolysis studied. Immobilized α -amylase on glass beads (covalent binding) and cation exchange resin (ioni...

In an age of unprecedented scientific achievement, I argue that the neurosciences are poised to transform our perceptions about life on earth, and that collaboration is needed to exploit a vast body of knowledge for humanity’s benefit. The scientific method distinguishes science from the humanities and religion. It has evolved into a professional, specialized culture with a common language that...