BACKGROUND The sensitivity and specificity of 18S rRNA polymerase chain reaction (PCR) in the detection of fungal aetiology of microbial keratitis was determined in thirty patients with clinical diagnosis of microbial keratitis. METHODS Corneal scrapings from patients were used for Gram stain, culture and PCR analysis. PCR was performed with primer pairs targeted to the 18S rRNA gene. The res...

OBJECTIVE Ultraviolet (UV) keratitis is a self-limited, inflammatory condition resulting in pain and temporary visual disturbance following acute UV radiation exposure. It may afflict mountaineers and other outdoor recreationalists because snow, water, and sand reflect a high percentage of UV radiation reaching the earth's surface. We examined the cases of UV keratitis that have occurred on Nat...

PURPOSE Introducing a simple image grading system to support the interpretation of in vivo confocal microscopy (IVCM) images in filamentous fungal keratitis. SETTING Clinical and confocal studies took place at the Department of Ophthalmology, Aarhus University Hospital, Denmark. Histopathological analysis was performed at the Eye Pathology Institute, Department of Neuroscience and Pharmacolog...

RATIONALE Relapsing polychondritis (RP) is a rare collagen disease characterized by inflammation and destruction of cartilage throughout the body. The paper details the clinical course of a case of RP with unique circumferential peripheral keratitis. PATIENT CONCERNS A 54-year-old Japanese woman was referred to the hospital presenting with auricular and ocular pain. DIAGNOSES Based on the a...

OBJECTIVE To evaluate the risk factors that may contribute to microbial keratitis in contact lens wearers. MATERIAL AND METHOD This prospective case-control study included 52 patients with contact lens related keratitis treated between 1 December 2006 and 15 October 2007 at the Faculty of Medicine, Siriraj Hospital. Controls were sixty-three contact lens users attending with disorders unrelat...

PURPOSE To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS Anterior chamber inoculation of the right eye of each mouse with various titers of HSV-1 (KOS strain) was performed. Bot...

tients are at risk for lagophthalmos and exposure-related keratitis. The post-LASIK neurotrophic status of these patients may further predispose them to infectious keratitis. The first case represents, to our knowledge, the earliest postLASIK human histopathologic finding (9 days post-LASIK). The neurotrophic cornea would certainly be a risk factor in the immediate postoperative period. The fir...

BACKGROUND Microbial keratitis is an infectious disease of the cornea characterised by inflammation and is considered an ophthalmic emergency requiring immediate attention. While a variety of pathogenic microbes associated with microbial keratitis have been identified, a comprehensive review identifying the diversity of species has not been completed. METHODS A search of peer-reviewed publica...

How to Treat Bacterial Keratitis Bacterial keratitis in dogs is a common disease that can be aggressive and may threaten vision. The exact pathogenesis is unknown. Culture of the cornea should be done when bacterial keratitis is suspected, and many suspected or confirmed cases are treated with cefazolin and tobramycin or with ciprofloxacin alone. All of these regimens provide a broad spectrum o...

Abstract Fungal keratitis is challenging to diagnose and treat remains a significant cause of blindness worldwide. The easiest most common method drug delivery for patients with fungal eye drop administration. However, the therapeutic effect traditional drops unsatisfactory, largely due intrinsic nature ocular barriers, which limit absorption; rapid decrease in concentration caused by tears; si...