Early myoclonic encephalopathy (EME) is a rare malignant epileptic syndrome. The erratic myoclonus with or without focal motor seizures, onset before 3 months of age, and persistent suppression-burst pattern in electroencephalograph (EEG) are accepted as the diagnostic criteria for EME. We report an 11 month old infant with EME which was secondary to non-ketotic hyperglycinemia.

Type 2 Diabetes Mellitus is one of metabolic disorder, which is characterized by elevation of blood glucose level as consequences of insulin resistance and insulin deficiency. By the history of illness, Diabetic patients because of various condition will experience various complications, either as acute (hypoglycemia, ketoacidosis, and Non-ketotic hyperosmolarity) or chronic complication (macro...

The work of Ulstrom and his associates,"2 has described many of the features of ketotic hypoglycemia, a syndrome of sporadic hypoglycemia associated with ketosis in children. These investigators have described the following characteristics: hypoglycemia rarely occurred before 18 months of age; it usually occurred after poor dietary intake; acetonuria was present; this kind of hypoglycemia was s...

We thank Drs. Kalra and and Baruah for their comments (1) on our article (2) in an effort improve the utility of our proposed b-cell–centric classification. We agree that “treatment” is more important than “classification.” We find it frustrating that governments and insurers often think otherwise, limiting therapies of choice on the basis of labels of diabetes mellitus (DM) that are not optima...

The clinical features of seven patients with non-ketotic hyperglycaemia who developed focal seizures are presented. All patients were alert except one who was mildly confused. Glucose values varied from 17.8 to 55.1 mmol/l, while calculated osmolarity values were elevated in all cases to a mild or moderate extent (299.1 to 346.5 mmol/l). In three cases diabetes mellitus was a new diagnosis. Fou...