The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish devel...

great eighteen chorale preludes arranged according to difficulty." DMA (Doctor of Musical Arts) thesis, de facto adviser of this essay, even though the topic is beyond his immediate interests, and even though the project was born before he joined the faculty at the University of Iowa. Thanks also to Katharina Malecki of Bärenreiter-Verlag for giving permission to use musical examples from their...

Endosomes are known to undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. A recent paper (Rowland et al, 2014) shows that contact sites between endosomes and the endoplasmic reticulum (ER) define the position and timing for fission. This uncovers an unanticipated role for the ER in controlling endos...

 In this paper, we consider a flexible skew-generalized normal distribution. This distribution is denoted by $FSGN(/lambda _1, /lambda _2 /theta)$. It contains the normal, skew-normal (Azzalini, 1985), skew generalized normal (Arellano-Valle et al., 2004) and skew flexible-normal (Gomez et al., 2011) distributions as special cases. Some important properties of this distribution are establi...

mulla sadra shirazi by his fundamentals like fundamentality of existence, existential gradation and the unity of being, believes that love equals being and explains how the love moves in all particles in the universe. he maintains that love is divine nature of human existence and it is full of wisdom and expediency sees. although the description of love by the theory of fundamentality of existe...