The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II–driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of foca...

The development of this article follows the search for a technique that automates the modelling and dynamics of any natural (dunes, slipping of mountainsides, glaciers...) or artificial (collapsing of buildings...) structure. In this study, the dynamics of the Argualas rock glacier (Pyrenees-Spain) has been investigated since 1991. A peculiarity of rocks glaciers is their sensitivity to environ...

The small GTPase RhoA has critical functions in regulating actin dynamics affecting cellular morphogenesis through the RhoA/Rho kinase (ROCK) signaling cascade. RhoA signaling controls stress fiber and focal adhesion formation and cell motility in fibroblasts. RhoA signaling is involved in several aspects of neuronal development, including neuronal migration, growth cone collapse, dendrite bran...

In different fields like decision making, psychology, game theory and biology, it has been observed that paired-comparison data like preference relations defined by humans and animals can be intransitive. The relations may resemble the well-known game of rock-paper-scissors. In the game, rock defeats scissors and scissors defeat paper, but rock loses to paper. Intransitive relations cannot be m...

Introduction: We have completed analysis of a new near-field rock count at the Mars Pathfinder landing site and determined that the previously published [1,2] rock count suggesting 16 % cumulative fractional area (CFA) covered by rocks is incorrect. The earlier value is not so much wrong (our new CFA is 20%), as right for the wrong reason: both the old and the new CFA’s are consistent with remo...

The high temperatures existing within a geothermal well preclude the use of most logging instrumentation which is necessary to study the wellbore and surrounding rock matrix. Possible solutions to this problem include cooling the wellbore and the surrounding rock by circulating fluid in the wellbore and by injecting fluid directly into the rock matrix. The latter method, however, is not preferr...

Interferon-stimulated gene 15 (ISG15) is known to interfere with viral replication and infection by limiting the viral infection of cells. Interferon-stimulated gene 15 (ISG15) interferes with viral replication and infectivity by limiting viral infection in cells. It also plays an important role in the immune response. In this study, tissue-specific expression of ISG15 in healthy rock bream sam...

Original scientific paper Rock burst is a common serious geological hazard in underground engineering, which seriously affects the progress of projects. The mechanism of rock burst can be explained by the distribution law of rock fragments and its fractal characteristics. A simulation experiment of rock burst was conducted with the granite samples under a biaxial loading machine system to analy...

Rho kinase (ROCK) is involved in various physiological functions, including cell motility, vasoconstriction, and neurite extension. Although a functional role of ROCK in nociception in the central nervous tissue has been reported in neuropathy, the peripheral function of this protein in hyperalgesia is not known. In this study, antinociceptive effects of AS1892802 [1-[(1S)-2-hydroxy-1-phenyleth...

The mechanisms by which lithology modulates geomorphic processes are poorly known. In the Oregon Coast Range (OCR), rhythmically bedded sandstones of the Eocene Tyee Formation underlie steep, soil-mantled hillslopes, with relatively uniform ridge-valley spacing. These characteristic landforms are perturbed where diagenetic variations manifest as resistant cliffs. Here we use petrology, rock mec...