This paper analyzes the impact of music file sharing on CD purchases. Traditionally , two arguments are opposed concerning the impact of the music file sharing on CD sales. On the one hand, MP3s downloads only reduces sales of legitimate. On the other hand, consumption of free MP3s could lead people to buy CD which they would never have bought otherwise (the “sampling effect”). Because the cour...

Flavopiridol (NSC @98%,L86-8275), a potent inhibitor of cyclin dependent kinase 1Jp34@ phosphorylation and kinase activity, is cur rently undergoing Phase I clinical testing as a potential antineoplastic agent. Previous studies have suggested that flavopiridol is cytostatic but not cytotoxic when applied to exponentially growing cells. In the present study, various human tumor cell lines were a...

And the Winner Is--Acquired: Entrepreneurship as a Contest with Acquisition as the Prize R&D incentives of new entrants to a market may be shaped by the prospects of being acquired by an incumbent. In this paper, we analyze a two-stage innovation game between one incumbent and a large number of entrants. In the first stage, firms compete to develop innovations of high quality. They do so by cho...

On-demand computing provides a new way for companies to manage and use their IT infrastructure. This model of corporate computing radically changes the way companies pay for their IT infrastructure, basing it on "pay per use" rather than on the fixed infrastructure investments such companies are accustomed to. A clear theoretical understanding of pricing on-demand computing is thus central to t...

Flavopiridol (L86-8275), a JV-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G, or G2 and is a potent cyclin-dependent kinase (CDK) 1 inhibitor. In this study, we used MCF-7 breast carcinoma cells that are wild type for p53 and pRb positive and contain CDK4-cycIin Dl and MDA-MB-468 breast carcinoma cells that are mutant p53, pRb negative, and lack CDK4-cyc...

Flavopiridol (NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and kinase activity, is currently undergoing Phase I clinical testing as a potential antineoplastic agent. Previous studies have suggested that flavopiridol is cytostatic but not cytotoxic when applied to exponentially growing cells. In the present study, various human tumor cell lines w...

cross-sectional survey We thank the reviewers for their time and thoughtful comments. To make the reviewer comments available to all of the co-authors, we have repeated the comments from all of the reviewers below. We have responded to the comments for each reviewer and have indicated the changes made in the manuscript. We are extremely grateful for your review of the manuscript. You have raise...