The biochemical changes which have been reported during and after hypothermia for cardiac surgery, and on which the literature is now considerable, are similar in man to those already found in animals. However, there are comparatively few references in the literature to investigations carried out in neurosurgical units, those of Gunton, Scott, Lougheed, and Botterell (1956) and Gray (1957) bein...

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Clinical practice guidelines (CPGs) relating to laboratory diagnostic testing are increasingly produced with the aim of standardizing practice and improving patient care based on the best available evidence. However, the production of a CPG is merely the first step in the process of getting evidence into practice, to be undertaken by laboratories and other stakeholders. This process should eval...

OBJECTIVE To compare the population-level impact of two World Health Organization-endorsed strategies for improving the diagnosis of tuberculosis (TB): same-day microscopy and Xpert MTB/RIF (Cepheid, USA). METHODS We created a compartmental transmission model of TB in a representative African community, fit to the regional incidence and mortality of TB and HIV. We compared the population-leve...