BACKGROUND Prior studies suggest that histamines may modulate the development of colorectal neoplasia. AIM To assess whether histamine receptor antagonist use was associated with adenoma formation. METHODS Patients (n = 2366) were drawn from three adenoma chemoprevention trials. All underwent baseline colonoscopy with removal of adenoma(s) and were deemed free of remaining lesions; they wer...

Lactation embodies a natural model of morphological, neurochemical, and functional brain plasticity. In this reproductive stage, the hippocampus of the female is less sensitive to excitotoxins in contrast to nulliparity. Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are known to be neuroprotective in several experimental models of brain lesion. Here, activation of the GH-IGF1 pitu...

Transporter-mediated processes in the lactating mammary gland may explain the significant accumulation of certain drugs in breast milk. The purpose of this study was to identify potential candidate drug transport proteins involved in drug accumulation in milk. Quantitative reverse transcription-polymerase chain reaction methods were developed to determine the relative RNA levels of 30 different...

The effects of dehydration on mechanisms of water balance and milk synthesis were investigated in ten lactating Gambian women who were fasting during Ramadan. Ten non-pregnant, non-lactating women acted as controls. Fasting consisted of total water abstention from 05.00 hours to 19.30 hours and was accompanied by high insensible water losses. Lactating women lost 7.6% of their total body water ...

We measured daily energy expenditure (DEE) and water turnover rates in lactating and non-lactating short beaked echidnas (Tachyglossus aculeatus) using the doubly labelled water technique during the lactation period in spring. Reproductively inactive echidnas were on average significantly heavier (median: 3354 g; range: 2929-3780 g; N=4) than lactating females (median: 2695 g; range: 2690-2715 ...

Some metabolic alterations were evaluated in Wistar rats which received control or low-protein (17%; 6%) diets, from the pregnancy until the end of lactation: control non-lactating (CNL), lactating (CL), low-protein non-lactating (LPNL) and lactating (LPL) groups. Despite the increased food intake by LPL dams, both LP groups reduced protein intake and final body mass was lower in LPL. Higher se...

ectopic paratliyroid adenoma might create a clinical dilemma in patients with hypercalcemia. radioisotopic scan is a sensitive and noninvasive method which can be useful in these patients. in this report a case of ectopic parathyroid adenoma is presented and the usefulness of tc-99m-mibi scintigraphy as compared with other modalities is discussed.

conclusions radiofrequency ablation may be used successfully in the treatment of parathyroid adenoma when a patient cannot tolerate surgery. case presentation a 47-year-old patient was referred to our hospital (namazi hospital, shiraz, iran) in april, 2015 with intracranial hemorrhage, as well as high serum calcium and pth (parathyroid hormone) levels (12.1 mg/dl and 1062 pg/ml, respectively), ...

Toxic milk (tx) is a copper disorder of mice that causes a hepatic accumulation of copper similar to that seen in patients with Wilson disease. Both disorders are caused by a defect in the ATP7B copper-transporting ATPase. A feature of the tx phenotype is the production of copper-deficient milk by lactating dams homozygous for the tx mutation; the milk is lethal to the pups. It has not been det...