OBJECTIVE Clinical practice guidelines (CPGs) are intended not only to provide supportive information for health care providers but also to act as a guide for health care policy decisions. However, extant CPGs do not always reach the same conclusions. The objective of this study was to compare recommendations for initial pharmacological treatment of new-onset epilepsy in adults as stated within...

OBJECTIVES Levetiracetam is a broad-spectrum antiepileptic drug (AED) which is currently licensed in the United States and the United Kingdom and Ireland for use as adjunctive treatment of focal-onset seizures and myoclonic seizures or generalized tonic-clonic seizures, occurring as part of generalized epilepsy syndromes. In the United Kingdom and Ireland, it is also licensed as monotherapy tre...

Epilepsy is a common neurologic disorder affecting approximately 1% of the population. The prevalence of active epilepsy in Kerman,Iran is 7.87/1000 individuals. The past decade has brought many advances to the treatment of epilepsy, including many new pharmacological agents. Lamotrigine is one of the new antiepileptic drugs. Lamotrigine has many side effects; the most important of which are al...

Development of epilepsy services in the northern region has included a baseline audit of the availability of pre-conceptual advice, AED prescribing, folic acid usage, vitamin K administration and pregnancy outcome in women with epilepsy which we now report. Patients, identified by community midwives, complete a standardized interview questionnaire with a research nurse. Delivery outcome is reco...

lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type i. till date, very few cases of lamotrigine overdose have been reported. the spectra of clinical effects of lamotrigine in acute overdose are not well established. in severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...

PURPOSE Impact of adverse effects of antiepileptic medications (AEDs) such as cognitive side effects (CSEs) on quality of life can be significant. Here we provide an extended follow-up to our earlier study to investigate the predictors of cognitive side effects (CSEs) and relative frequency of CSEs among all commonly used AEDs. METHODS In this retrospective study, medical records of 2860 adul...

PURPOSE Evaluation of ketogenic diet (KD) therapies for seizure control during pregnancy when safety and appropriate management become considerations. Until now, no information has been available on seizure reduction and human pregnancy related outcomes in women treated with KD therapies. METHOD We describe two cases of pregnant women with epilepsy treated with KD therapy either as monotherap...

Understanding the consumption patterns of antiepileptic drugs (AEDs) is important since epilepsy generates a large percentage of healthcare costs and the adverse effects of antiepileptic drugs may have a significant impact on the patients’ quality of life. This is why it may be beneficial to document consumption patterns among the epileptic population of the Western Málaga district. Since the o...

Understanding the consumption patterns of antiepileptic drugs (AEDs) is important since epilepsy generates a large percentage of healthcare costs and the adverse effects of antiepileptic drugs may have a significant impact on the patients’ quality of life. This is why it may be beneficial to document consumption patterns among the epileptic population of the Western Málaga district. Since the o...

PURPOSE To determine the influence of epilepsy and its treatment on pregnancy and its outcome. DESIGN Controlled, observational study. SETTING National Health Service maternity hospitals in Liverpool and Manchester regions. POPULATION 277 women with epilepsy (WWE) and 315 control women. METHODS WWE were recruited from antenatal clinics. Controls were matched for age and parity but not g...