In this report, we compare the function of the human beta-globin locus control region (LCR) in three K562 erythroleukemia cell assays, including (1) a transient transfection assay for "classical" enhancer activity, (2) a colony assay that detects "productive integration events," and (3) an assay that detects the ability of LCR fragments to confer hemin inducibility on linked, stably integrated ...

The formation and plasticity of synaptic connections rely on regulatory interactions between pre- and postsynaptic cells. We show that the Drosophila heparan sulfate proteoglycans (HSPGs) Syndecan (Sdc) and Dallylike (Dlp) are synaptic proteins necessary to control distinct aspects of synaptic biology. Sdc promotes the growth of presynaptic terminals, whereas Dlp regulates active zone form and ...

Collective migration of epithelial cells underlies diverse tissue-remodeling events, but the mechanisms that coordinate individual cell migratory behaviors for collective movement are largely unknown. Studying the Drosophila follicular epithelium, we show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing ...

O artigo objetivou compreender o processo de socialização profissional da mulher em espaços políticos. Utilizou-se pesquisa exploratória qualitativa, com dez entrevistas profundidade vereadoras e deputadas, realizadas por meio roteiro semiestruturado pautado nas três fases (HUGHES; 1958; DUBAR, 2005): “Passagem através do espelho”, “Instalação dualidade” “Ajuste concepção si”. Notou-se que as m...

lstituto Beni Culturali (Institute for Cultural Heritage) is the cultural institution of Regione Emilia Romagna. IBC web site [6] has been completely revised in cooperation with Hypermedia Open Center [S], the laboratory of the Electronics and Information Department at Politecnico di Milano. We adopted W2000 model for requirements analysis and for the analysis and organization of the applicatio...

BACKGROUND The aims of the current study were: a) to quantitatively compare data obtained by Short Message Service (SMS) with data from a telephone interview, b) to investigate whether the respondents had found it acceptable to answer the weekly two SMS questions, c) to explore whether an additional weekly third SMS question would have been acceptable, and d) to calculate the total cost of usin...

plagioclase and spinels in LAR 06319. Fig. 1: Thin-section photomicrograph of LAR 06319, 37, in transmitted light. Olivine-Phyric Shergottite LAR 06319: Its relation to the enriched components in Martian basalts. A. Basu Sarbadhikari 1,2 , J.M.D. Day 3 , Y. Liu 1 , and L.A. Taylor 1 ; 1 Planetary Geosciences Institute, Dept. of Earth & Planetary Sciences, Univ. of Tennessee, Knoxville, TN 37996...

This work presents a low-aspect-ratio (LAR) inertial microfluidic design compatible with roll-to-roll (R2R) hot embossing for size-based cell or microparticle separation in a low-cost and disposable format. The device consists of two segments of LAR channels in which inertial lift forces are used to differentiate lateral positions based on size for separation downstream. Separation of 18μm and ...

PURPOSE To compare organ specific cancer incidence risks for standard and complex external beam radiotherapy (including cone beam CT verification) following breast conservation surgery for early breast cancer. METHOD Doses from breast radiotherapy and kilovoltage cone beam CT (CBCT) exposures were obtained from thermoluminescent dosimeter measurements in an anthropomorphic phantom in which th...

The compatibility of a 2% chlorhexidine gluconate/70% isopropyl alcohol (CHG/IPA) skin preparation with a gum mastic liquid adhesive (GMLA) and liquid adhesive remover (LAR) was assessed in healthy volunteers. Twenty subjects completed test material combination with microbial sampling at 3- and 7-day time points. Mean log10 reductions from baseline for normal flora were assessed. There was no s...