surgery has opened up the possibility to change the corneal curvature to compensate for refractive errors of the eye. In the case of small spot hyperopic laser in situ keratomileusis (H–LASIK), excimer laser systems produce a steepness of the cornea by ablating mainly at the periphery of the cornea. Hyperopic laser in situ keratomileusis (H-LASIK) treatments induce aberrations1. Other studies2,...

The subperineurial injection of /3#‘-iminodipropionitrile (IDPN) into rat sciatic nerves resulted in focal disorganization of the axonal cytoskeleton characterized by segregation of neurofilaments and microtubules. Shortly after injection, microtubules clustered together to form a central channel, while neurofilaments became chaotically arrayed between the microtubule channel and axolemma. Elec...

Growing axons receive a substantial supply of tubulin and other proteins delivered from sites of synthesis in the cell body by slow axonal transport. To investigate the mechanism of tubulin transport most previous studies have used in vitro models in which the transport of microtubules can be visualized during brief periods of growth. To investigate total tubulin transport in neurons displaying...

Previous experiments have demonstrated that 4 S RNA is transported axonally during the reconnection period of optic nerve regeneration in goldfish. The present experiments were performed to determine whether 4 S RNA is transported axonally during later, maturational stages of nerve regeneration and to examine some of the characteristics of 4 S RNA in regenerating axons. [“H]Uridine was injected...

PURPOSE To establish morphologic and functional changes in the rat cornea after 20% ethanol-mediated epithelial flap creation. METHODS The epithelial flap was detached using 20% ethanol and then repositioned. On the other eye, the corneal epithelium was mechanically scraped. The morphologic changes were examined by light and transmission electron microscopy (LM and TEM). Terminal deoxynucleot...

PURPOSE To evaluate laser in situ keratomileusis (LASIK) for induced hyperopia after radial keratotomy. METHODS Twenty eyes had LASEK for induced hyperopia after radial keratotomy. All eyes were treated using the Nidek excimer laser (EC-5000) and the Hansatome microkeratome with a 905-mm ring and 180-mm plate. Hyperopic correction was done using a 5.5 to 7.5-mm ablation zone. RESULTS Mean p...

A mong cytoskeletal systems, the intermediate filaments (IFs) 1 are unique because they are composed of different proteins in different tissues. These proteins share a common tripartite structure composed of an NH 2 -terminal head domain, a coiled-coil rod domain, and a COOH terminus of varying length. They are subdivided into six IF classes according to their amino acid sequence similarity (fo...

determinants of early onset haze were retrospectively explored in patients who had been undergone laser-assisted sub-epithelial keratectomy (lasek) in a private eye clinic. the technique included creating an epithelial flap following 20 seconds exposure to 20% alcohol. ‘optimized’ ablation profile was used by allegretto laser (wavelight technologie). following repositioning of the flap, a singl...

Most of the published work on the phenomenon of axoplasmic transport has been directed towards determining the site of synthesis and the chemical nature of materials involved, the mechanisms responsible for their movement, and the rates at which they are transported (see refs. 1, 23, 44, 49, 53 for reviews). However, following the suggestion of Taylor and Weiss 68, several workers, notably Lase...