ANGDelMut is a web-based tool for predicting the functional consequences of missense mutations in the angiogenin (ANG) protein, which is associated with amyotrophic lateral sclerosis (ALS). Missense mutations in ANG result in loss of either ribonucleolytic activity or nuclear translocation activity or both of these functions, and in turn cause ALS. However, there are no web-based tools availabl...

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We investigated the neural basis of so-called “object-based attention” by examining patient D.F., who has visual form agnosia caused by bilateral damage to the lateral occipital (LO) area of the ventral visual stream. We tested D.F.’s object-based attention in two ways. In the first experiment, we used a spatial cueing procedure to compare the costs associated with shifting attention within ver...

A transversely isotropic model in which the tilt is constrained to be normal to the dip (DTI model) allows for simplifications in the imaging and velocity model building efforts as compared to a general TTI model. Though this model, in some cases, can not be represented physically like in the case of conflicting dips, it handles all dips with the assumption of symmetry axis normal to the dip. I...

Mutations in the optineurin (OPTN) gene cause amyotrophic lateral sclerosis (ALS). We previously reported three types of OPTN mutation in Japanese ALS subjects. Here, to identify the OPTN mutations in individuals of different ethnicity, we screened 563 sporadic ALS (SALS) subjects and 124 familial ALS (FALS) subjects who were mainly Caucasian. We found a c.964T>C synonymous variation in exon 8....

Studies on the therapeutic potential of adult stem cells in the G93A animal model of amyotrophic lateral sclerosis (ALS) Dissertation Submitted in partial fulfillment of the requirements for the degree Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). Behav Brain Res 213:82-87. Intraspinal injection of human umbilical cord blood-derived cells ...

ADVANCES in Neurotechnology are based on the recording and analysis of brain activity. BrainComputer Interfaces (BCIs) constitute a very active research area within Neurotechnology. BCIs make it possible for brain activity to be directly translated into control commands and thus enable a communication channel that is independent of muscle control. One major goal of this research is to help peop...

In the visual cortex of the cat and ferret, it is established that orientation selectivity is the consequence of experience-dependent plasticity. Recent experiments, however, indicate that the layout of orientation maps is remarkably stable and experience-independent. We present a model to account for these seemingly paradoxical results. In this model, a scaaold consisting of anisotropic latera...

ANGDelMut is a web-based tool for predicting the functional consequences of missense mutations in the angiogenin (ANG) protein, which is associated with amyotrophic lateral sclerosis (ALS). Missense mutations in ANG result in loss of either ribonucleolytic activity or nuclear translocation activity or both of these functions, and in turn cause ALS. However, there are no web-based tools availabl...

In fact, besides the avoidance of morbidities associated with traditional anterior or posterior interbody fusion techniques, including injury to visceral, vascular or neural structures, minimally invasive LLIF enables the surgeon to spare the anterior and posterior longitudinal ligaments during the surgical approach, and to implant cages with a large footprint, designed to span the dense apophy...