Please direct correspondence to Raymond Xu at [email protected] oday, due to its inherent specificity and sensitivity, the most prevalent bioanalytical technique in drug development is liquid chromatography tandem mass spectrometry (LC–MS-MS). This technique is regarded widely as the preferred tool for quantitative determination of drug and metabolites from biological matrices including pla...

Korean ginseng (Panax ginseng C.A. Meyer) contains several types of ginsenosides, which are considered the major active medicinal components of ginseng. The types and quantities of ginsenosides found in ginseng may differ, depending on the location of cultivation, making it necessary to establish a reliable method for distinguishing cultivation locations of ginseng roots. P. ginseng roots produ...

The carob tree (Ceratonia siliqua L.) is a native of the Mediterranean basin with several applications in the food, textile and cosmetics industries [1]. It belongs to the Caesalpinaceae sub-family of the family Leguminoseae [2].The pods of the carob fruit have long been used as a feed for livestock and in human nutrition, including sweets, biscuits and processed drinks, because of its high sug...

A simple, precise, accurate stability-indicating gradient reversed-phase high-performance liquid chromatographic (RP-HPLC) method was developed for the quantitative determination of zotepine (ZTP) in bulk and pharmaceutical dosage forms in the presence of its degradation products (DPs). The method was developed using Phenomenex C18 column (250 mm×4.6 mm i.d., 5 µm) with a mobile phase containin...

Ginger (Zingiber officinale R.), lemon (Citrus limon L.) and mint (Mentha sp.) are commonly consumed medicinal plants that have been of interest due to their health benefits purported antioxidant capacities. This study was conducted on the premise no previous has performed elucidate phenolic profile ginger, herbal tea infusion (GLMT). The aim investigate characterise contents lemon, GLMT, as we...

BACKGROUND Peptide-based analysis of whole blood using electrospray tandem mass spectrometry (MSMS) in multiple reaction monitoring (MRM) mode enables rapid detection and sequence confirmation of clinically significant hemoglobin (Hb) variants. We applied a similar, quantitative approach to the measurement of delta:beta-globin peptide ratios as potential surrogate markers of HbA(2), a biomarker...

We present a dynamic coarse-graining technique that allows one to simulate the mechanical unfolding of biomolecules or molecular complexes on experimentally relevant time scales. It is based on Markov state models (MSMs), which we construct from molecular dynamics simulations using the pulling coordinate as an order parameter. We obtain a sequence of MSMs as a function of the discretized pullin...

SUMMARY Markov state models (MSMs) for the study of biomolecule folding simulations have emerged as a powerful tool for computational study of folding dynamics. MSMExplorer is a visualization application purpose-built to visualize these MSMs with an aim to increase the efficacy and reach of MSM science. AVAILABILITY MSMExplorer is available for download from https://simtk.org/home/msmexplorer...

Bouea macrophylla Griff is a member of the Anacardiaceae family, which has edible fruits. Due to high nutritional value, appealing taste, and attractive color, fruit juice B. potential be developed as functional beverage. The present study was conducted determine phytochemical profile using GC-MS LC-MS/MS. analysis performed with Agilent Technologies 7890 Gas Chromatograph automated sampling ta...