as axon guidance cues. Both plexin B1 and plexin B2 are expressed during mouse kidney development. Inbred plexin B2 knockout (PB2 KO) mice die prenatally with defects in olfactory bulb development, neuronal proliferation and neural tube closure (exencephaly). We report here that these PB2 KO mice have defects also in kidney morphogenesis. In PB2 / embryos the kidneys are smaller and the number ...

Divalent cations are involved in the function of bacteriorhodopsin (bR) as a light-driven proton pump. If cations are removed from purple membranes they become blue. Divalent cations such as Ca2+ or Pb2+ or trivalent ions, can be stoichiometrically titrated back on to these deionized membranes. The color transitions as a function of ion concentration for Ca2+ or Pb2+ are precisely comparable an...

as axon guidance cues. Both plexin B1 and plexin B2 are expressed during mouse kidney development. Inbred plexin B2 knockout (PB2 KO) mice die prenatally with defects in olfactory bulb development, neuronal proliferation and neural tube closure (exencephaly). We report here that these PB2 KO mice have defects also in kidney morphogenesis. In PB2 / embryos the kidneys are smaller and the number ...

The influenza virus polymerase is formed by the PB1, PB2 and PA subunits and is required for virus transcription and replication in the nucleus of infected cells. As PB2 is a relevant host-range determinant we expressed a TAP-tagged PB2 in human cells and isolated intracellular complexes. Alpha-importin was identified as a PB2-associated factor by proteomic analyses. To study the relevance of t...

We report herein a fluoroionophore sensor derivated from tryptophan that shows high sensitivity (detection limit up to 0.15 microM) and specific selectivity for lead ion (Pb2+) over Ca2+, Cd2+, Co2+, Cr3+, Cu2+, K+, Mg2+, Na+, Fe2+, Mn2+, Ni2+ and Zn2+ in aqueous solution.

A simple fluorescent chemosensor 1 exhibits a 40-fold fluorescence enhancement upon addition of lead ion and yet is insensitive to most of univalent and divalent metal ions. The high affinity of 1 toward Pb2+ presumably results from the cooperative binding behaviors of two potential metal binding sites: the dicarbonyl and the 15-monoazacrown-5 ether.

The discharge of lead containing effluents into the environment and water bodies is harmful for the human, animals, aquatic flora and fauna. Herein, a novel surface engineered magnetic nanoparticle for removing Pb2+  ions was studied. After surface modification of the magnetite by 3-amino-propyltriethoxysilane (APTES) magnetic nanoparticles with covalently linked porphyrins were synthesize...

Hydrothermal reactions of a lead(II) salt with 3-aminopyrazine-2-carboxylic acid (HL1) gave rise to a series of lead(II) coordination compounds (1–6) having zero, one, two and three dimensional structures. X-ray diffraction structural analyses reveal that complexes [Pb(L1)2]2 (1) and [Pb(L1)(OCHNH2)(η-OCHO)]2 (2) possess dinuclear structures, containing a centre of symmetry. Complexes [Pb2(L1)4...

the discharge of lead containing effluents into the environment and water bodies is harmful for the human, animals, aquatic flora and fauna. herein, a novel surface engineered magnetic nanoparticle for removing pb2+ ions was studied. after surface modification of the magnetite by 3-amino-propyltriethoxysilane (aptes) magnetic nanoparticles with covalently linked porphyrins were synthesized. two...