A quantitative structure-activity relationship (QSAR) study was conducted for the prediction of inhibitory activity of 1-phenyl[2H]-tetrahydro-triazine-3-one analogues as inhibitors of 5-Lipoxygenase. The inhibitory activities of the 1-phenyl[2H]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (MLR) ...

In this paper a methodology for estimation in kernel-induced feature spaces is presented, making a link between the primal-dual formulation of Least Squares Support Vector Machines (LS-SVM) and classical statistical inference techniques in order to perform linear regression in primal space. This is done by computing a finite dimensional approximation of the kernel-induced feature space mapping ...

We study randomized sketching methods for approximately solving least-squares problem with a general convex constraint. The quality of a least-squares approximation can be assessed in different ways: either in terms of the value of the quadratic objective function (cost approximation), or in terms of some distance measure between the approximate minimizer and the true minimizer (solution approx...

This paper develops and analyzes two least-squares methods for the numerical solution of linear, stationary incompressible Newtonian fluid flow in two and three dimensions. Both approaches use the L norm to define least-squares functionals. One is based on the stress-velocity formulation (see section 3.2), and it applies to general boundary conditions. The other is based on an equivalent formul...

The Cubed Sphere grid is an important tool to approximate functions or data on the sphere. We introduce approximation framework this based least squares and a suitably chosen subspace of spherical harmonics. main claim that for equiangular with step size π/(2N), relevant harmonics one all SH degree less than 2N. This choice, which matches Nyquist’s cutoff frequency along equatorial great circle...