BACKGROUND Patients with hypertension and left ventricular hypertrophy (LVH) are prone to develop heart failure. We tested the hypothesis that compensatory LVH is associated with normalization of myocardial oxygen consumption and that this occurs at the expense of a decrease in the ratio between cardiac work and oxygen consumption (efficiency). METHODS AND RESULTS Nine hypertensive men with L...

Introduction: Left ventricle hypertrophy (LVH) is an important risk factor for cardiovascular morbidity and mortality. It is characterized by a thickening of the walls of the left ventricle. The transthoracic echocardiogram is a very accurate method for LVH detection. However, the electrocardiogram (ECG) offers an alternative method in diagnosing LVH, besides being less expensive and easier to ...

Background Normalised left ventricular mass (LVM) is a powerful prognostic tool. Traditionally, normalising has been achieved by indexing LVM to body surface area (BSA). A recent ‘Multiethnic Study of Atherosclerosis’ (MESA) sub-study demonstrated indexing LVM to height is more sensitive at identifying left ventricular hypertrophy (LVH) associated with cardiovascular events and all-cause death....

Left ventricular hypertrophy (LVH) is an independent marker of mortality in hypertension. Although the mechanisms contributing to LVH are complex, inflammation and oxidative stress may favor its development. We analyzed the association of the phagocytic NADPH oxidase-mediated superoxide anion release and LVH in patients with essential hypertension and the role of cardiotrophin-1 (CT-1) and inte...

Background Study purpose To detect differences in extracellular volume (ECV) and systolic strain in hypertensive patients with LVH as compared to hypertensive patients without LVH and age-matched controls. Background: Increased ECV due to diffuse myocardial fibrosis in hypertensive patients may be an underlying mechanism contributing to increased cardiovascular risk. Moreover HTN patients with ...

Objective: To estimate serum uric acid in essential hypertension and its correlation with left ventricular hypertrophy (LVH) patients presenting at a tertiary care hospital. Study Design: Cross Sectional study. Setting: Department of Cardiology Medicine, BMC Liaquat University Medical Health Sciences Jamshoro/Hyderabad NICVD Hyderabad, Sindh. Period: July 2018 to January 2021. Material & Me...

When acute myocardial infarction occurs in patients with hypertension and left ventricular hypertrophy (LVH), the incidence of sudden cardiac death increases markedly. Possible explanations include increased size of the occluded vascular bed secondary to more extensive atherosclerotic coronary vascular disease in the presence of hypertension, decreased coronary reserve secondary to LVH, and int...

MALIK,ASRAR B., TOMIO ABE,HUGH O'KANE, AND ALEXANDER S. GEHA. Cardiac function, coronary flow, and oxygen consumption in stable left ventricular hypertrophy. Am. J. Physiol. 225( 1) : 185-191. 1973.-We have compared cardiac function, coronary flow, and oxygen consumption of the canine left ventricle in stable hypertrophy (LVH) with those of the normal left ventricle (N). LVH was produced by ban...

A rapidly emerging body of literature implicates a pivotal role for the Ca2+-calmodulin-dependent phosphatase calcineurin as a cellular target for a variety of Ca2+-dependent signaling pathways culminating in left ventricular hypertrophy (LVH). Most of the recent experimental support for this hypothesis is derived from in vitro studies or in vivo studies in transgenic mice expressing activated ...