Previous studies have demonstrated that a single, topical application of a novel, long-acting transdermal fentanyl solution provides analgesic fentanyl concentrations for at least 4 days. The objective of this study was to describe the margin of safety following application at multiples of the therapeutic dose. Twenty-four laboratory dogs were administered a single placebo or 1×, 3×, or 5× mult...

The epithelium of the avascular, noninnervated lens was used to study the influence of isoproterenol on cell division. Contrary to the well-known and specific stimulation of deoxyribonucleic acid (DNA) synthesis and cell division in the salivary glands of rats and mice by this catecholamine, the rat lens epithelium responded to a single dose of either locally or systemically administered drug w...

In 2011, the International Commission on Radiological Protection issued a statement on tissue reactions (formerly termed non-stochastic or deterministic effects) to recommend lowering the threshold for cataracts and the occupational equivalent dose limit for the crystalline lens of the eye. Furthermore, this statement was the first to list circulatory disease (cardiovascular and cerebrovascular...

PURPOSE GBM recurrence primarily occurs inside or near the high-dose radiation field of original tumor site requiring greater than 100 Gy to significantly improve local control. We utilize 4π non-coplanar radiotherapy to test the feasibility of planning target volume (PTV) margin expansions or extreme dose escalations without incurring additional radiation toxicities. METHODS 11 GBM patients ...

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key enzyme that regulates cholesterol synthesis, lower serum cholesterol by increasing the activity of low density lipoprotein (LDL) receptors in the liver. In rat liver slices, the dose-response curves for inhibition of [14C]acetate incorporation into cholesterol were similar for the active acid forms of lovastatin, s...

presented as: A Multimarker Strategy for Risk Prediction in Heart Failure: Application of Novel Methods in a Community Cohort. American Heart Association 2008 Scientific Sessions, Elizabeth-Barrett Connor Award Finalist, Oral Presentation November 9, 2008. New Orleans, LA. Word Count: Total 5992 Tables: 4 Figures: 1 Journal Subject Codes: [8] Epidemiology, [110] Congestive Heart Failure by gest...

Predicting and controlling the concentrations of redox-sensitive elements are primary concerns for environmental remediation of contaminated sites. These predictions are complicated by dynamic flow processes as hydrologic variability is a governing control on conservative and reactive chemical concentrations. Subsurface heterogeneity in the form of layers and lenses further complicates the flow...