Obesity is associated with increased cardiovascular morbidity and mortality, in part through development of hypertension. Recent observations suggest that the cardiovascular actions of leptin may help explain the link between excess fat mass and cardiovascular diseases. Leptin is an adipocyte-derived hormone that acts in the central nervous system to promote weight loss by decreasing food intak...

PURPOSE OF REVIEW A fundamental advance in our understanding of endocrine control of energy balance and body weight came with the discovery of the adipocyte-derived hormone leptin. The leptin pathway appeared to be the long-sought peripheral signal pathway from the adipose tissue to the brain involved in the regulation of feeding and energy balance. RECENT FINDINGS Initially, leptin was consi...

Thermal stress is a unique and complex process which alters the normal physiological mechanisms. Heat shock proteins (HSPs) are known to be highly conserved ubiquitous synthesized in response several stimuli. The HSP inducers have been categorized as environmental (heat shock, UV radiation, heavy metals, amino acids, oxidative stress, etc.) pathological (bacterial or parasitic infections, fever...

Sports it is the best way to activate vital processes of different organs body hormones affect activity living organisms, so physiological changes occur across all systems as a result exercise. The study aims find out effect anaerobic exercise on concentrations irisin hormone and some hormonal variables in male sports practitioners, correlation between studied variables, with each other, mass c...

Leptin, a peptide discovered more than 10 years ago, decreases food intake and increases sympathetic nerve activity to both thermogenic and non-thermogenic tissue. Leptin was initially believed to be an anti-obesity hormone, owing to its metabolic effects. However, obese individuals, for unknown reasons, become resistant to the satiety and weight-reducing effect of the hormone, but preserve lep...

Leptin is a hormone produced by the adipose tissue that acts in the brain, stimulating white fat breakdown. We find that the lipolytic effect of leptin is mediated through the action of sympathetic nerve fibers that innervate the adipose tissue. Using intravital two-photon microscopy, we observe that sympathetic nerve fibers establish neuro-adipose junctions, directly "enveloping" adipocytes. L...

OBJECTIVE The aim of this study was to determine whether equol excretion status and plasma hormone and leptin concentrations can be influenced by consumption of a probiotic supplement. A secondary focus was to investigate whether male equol excretors have a hormone profile consistent with reduced prostate cancer risk. DESIGN The design was a randomized, single-blinded, placebo-controlled, par...

Excess or loss of body fat can be associated with infertility, suggesting that adequate fat mass is essential for proper reproductive function. Leptin is an adipocyte-derived hormone that is involved in the regulation of food intake and energy expenditure, and its synthesis and secretion are markedly increased in obesity. Short-term administration of leptin accelerates the onset of puberty in n...

Ob-Rb: Long isoform of leptin receptor. Ob-Ra, Ob-RcÖOb-Rf: Short isoforms of leptin receptor. FSH: Follicle stimulating hormone. IGF-I: Insulin-like growth factor type 1. BCL-2: B-cell lymphoma 2. Bax: Bcl-2-associated X protein. DMEM: Dulbecco’s Modified Eagle Medium. ER: Estrogen receptor alpha. ER: Estrogen receptor beta. AR: Androgen receptor. LHR: Luteinizing hormone receptor. FSHR: Folli...