Background Beta-thalassemia is the most common hematology disease in human and leptin is one of the hormone that produce by adiposities cells. The purpose of this study was to investigate the relationship between serum leptin level and thyroid hormones in children with major beta-thalassemia. Materials and Methods This descriptive-cross sectional study was performed on 90 children aged 6-16...

Abstract Spexin (SPX) is a pleiotropic peptide with highly conserved protein sequence from fish to mammals and its biological actions are mediated by GalR2/GalR3 receptors expressed in target tissues. Recently, SPX was found be novel satiety factor models but whether the has similar function still unknown. Using mouse as model for mammalian species, functional role of feeding control mechanisms...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

the aim of this study was to investigate the effect of acute swimming stress on plasma corticosterone and leptin levels in female and male rats. thirty- seven adult male (n=20) and female (n=20) sprague dawley rats (200-250 g weight) were used. the leptin and corticosterone levels were measured following swimming stress (10 minutes) or no stress. plasma leptin and corticosterone were measured b...

background beta-thalassemia is the most common hematology disease in human and leptin is one of the hormone that produce by adiposities cells. the purpose of this study was to investigate the relationship between serum leptin level and thyroid hormones in children with major beta-thalassemia. materials and methods this descriptive-cross sectional study was performed on 90 children aged 6-16 yea...

background & objectives: several epidemiological studies have indicated factors such as leptin level, adiponectin and plasma adiponectin-to-leptin index to be the predicting biomarkers for cardiovascular diseases. given the importance of healthy nutrition and adequate exercise in reducing the risk of atherosclerosis, this study aimed to investigate the effects of fasting and aerobic exercise on...

background leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus. conclusions it is speculated that lower serum leptin levels in diabetic patients may be a consequence of male gender. moreover, results suggest that serum leptin level in women is influenced differently than that in men. results the serum leptin level i...

Introduction: Ghrelin, increases food intake, decreases T3 and T4 concentrations and stimulates insulin release, while leptin reduces food intake and suppresses appetite. Considering the importance of thyroid hormones, ghrelin and leptin in body metabolism, the purpose of this study was to investigate the effect of interactions between ghrelin and leptin (injected via ICV route) and plasma T...