BACKGROUND AND PURPOSE Recent work has shown that fluid-attenuated inversion recovery (FLAIR) imaging with contrast enhancement is highly sensitive for detecting subarachnoid space disease. We hypothesized that contrast-enhanced FLAIR imaging has superior sensitivity to contrast-enhanced T1-weighted MR imaging in detecting leptomeningeal metastases. METHODS Sixty-eight patients referred for s...

The prognosis of leptomeningeal dissemination of recurrent glioblastoma is poor, and chemotherapy results in minimal palliative efficacy. Temozolomide (TMZ) is an established therapy for patients with malignant glioma and the standard of care in parenchymal gliomas; however, few reports have been published with regard to its use for the treatment of leptomeningeal dissemination. Only one report...

Approximately 30%-%0% of patients with HER2-positive breast cancer will develop central nervous system (CNS) metastasis. Trastuzumab deruxtecan (T-DXd) is known to have clinically relevant activity in HER2- positive metastatic (MBC) who progressed on prevsious lines treatment. DESTINY-Breast01 and DESTINY-Breast03 highlighted the intracranial response long-lasting clinical T-DXd MBC patients. I...

2026 Background: Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and effort sought to prospectively validate a revised response assessment in metastasis. Methods: Coded paired cerebrospinal 20 patients with metastases from solid cancers at baseline follow-up after treatment instructions were provide...

Leptomeningeal seeding is a strong negative prognostic factor for medulloblastoma (MB). The mechanism of leptomeningeal seeding is unclear but may involve epigenetic regulation. In this study, we evaluated the feasibility of a histone deacetylase (HDAC) inhibitor, panobinostat, in the suppression of MB leptomeningeal seeding. Panobinostat decreased the cell viability and proliferation, inducing...

BACKGROUND AND PURPOSE To develop an MR imaging method that improves detection of leptomeningeal disease when compared with the current reference standard, contrast-enhanced T1-weighted imaging. METHODS We investigated the cases of 10 children who were at high risk of intracranial leptomeningeal disease (Sturge-Weber syndrome and medulloblastoma). The cases of Sturge-Weber syndrome were inves...