background: the development of toxicity tests regarding toxic responses of different fish species could be more effectively used in predictive toxicology and risk assessment. in this study lethal concentrations (lc50-96 h) values of copper sulphate an important toxic industrial pollutant, on capoeta fusca were determined. behavioral changes at different concentrations of cuso4 were determined f...

Marrow stromal cells (MSCs, also termed mesenchymal stem cells) have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking. To assess the effects of MSCs on survival after lethal irradiation, we infused syngeneic MSCs (either as immortalized MSCs clones or primary MSCs) intravenously into wild-type...

The nontoxic mutant lethal factor (mLF; which has the E687C substitution) and functional protective antigen (PA63) of Bacillus anthracis were evaluated for their use as mucosal vaccines against anthrax in A/J mice. Intranasal vaccination of three doses of 30 microg of mLF or 60 microg of PA63 elicited significant serum and mucosal antibody responses, with anthrax lethal toxin-neutralizing titer...

BACKGROUND Regular aspirin use probably protects against some malignancies including prostate cancer (PC), but its impact on lethal PC is particularly unclear. OBJECTIVE To investigate the association between regular aspirin and (1) the risk of lethal PC in a large prospective cohort and (2) survival after PC diagnosis. DESIGN, SETTING, AND PARTICIPANTS In 1981/82, the Physicians' Health St...

I propose that a lethal (L. letalis) defect in a foetus or newborn be understood as: (1) a developmental anomaly that leads to spontaneous abortion, immature delivery, or intrauterine death; (2) a developmental anomaly leading to the premature death of a live-born child, irrespective of any therapy that may be applied; and (3) a developmental anomaly classified as grounds for legal abortion. De...