A 35-year-old female received right hemicolectomy for a poorly differentiated adenocarcinoma of the ascending colon with lymph node metastasis (1/28) in February 1997. CEA was 1.68 ng/microl prior to colectomy. Adjuvant chemotherapy with weekly 5-FU and leucovorin intravenously was started following surgery and discontinued after 17 doses in May 1997. She received bilateral salpingo-ophorecctom...

OBJECTIVE Adjuvant chemotherapy with oral uracil/tegafur plus leucovorin has been acknowledged to be a standard treatment for Stage II or III cancer of the colon. The objective of the study was to examine the health-related quality of life during treatment in patients with colorectal cancer who receive oral uracil/tegafur plus leucovorin. METHODS Health-related quality of life was assessed at...

May and coworkers (l-3) demonstrated that the production of a scorbutic state in monkeys led to the development of a megaloblastic anemia, a condition which responded promptly to treatment with pteroylglutamic acid (PGA) or to very much smaller amounts of synthetic citrovorum factor (leucovorin or folinic acid-SF) .I It has been shown that the administration of ascorbic acid to normal human sub...

The occurrence in human urine of a factor labile to heat and alkali which replaces citrovorum factor (CF; 5-formyl-5,6,7 ,%tetrahydrofolic acid; 5-formyl-THFA) in supporting the growth of Leuconostoc citrovorum, strain 8081 (Pediococcus sp. (1)) has been observed (2). This growth activity is lost upon autoclaving (pH 6.0 to 7.0) or during storage of urine at room temperature at pH 4.5 or above....

The inhibitory action of sodium sulfadiazine on the growth of psittacosis virus (6BC) in embryonated eggs is readily reversed by citrovorum factor but not by small amounts of vitamin B(12). In embryonated eggs, the pteroylglutamic acid analogues, 9-methylpteroylglutamic acid and 4-aminopteroylaspartic acid, produced some suppression of the growth of psittacosis virus (6BC). 4-Aminopteroylglutam...

Jukes (1) and Broquist et al. (2) reported that the addition of formate or serine to incubating cells of an A-Methopterin-resistant strain of Xtreptococcus.faecalis increased the amount of citrovorum factor (CF, folinic acid) which was formed from pteroylglutamic acid (PGA). This finding suggested that ‘Lformate-carbon” was incorporated into the structure of CF. Under appropriate conditions an ...

Jukes (1) and Broquist et al. (2) reported that the addition of formate or serine to incubating cells of an A-Methopterin-resistant strain of Xtreptococcus.faecalis increased the amount of citrovorum factor (CF, folinic acid) which was formed from pteroylglutamic acid (PGA). This finding suggested that ‘Lformate-carbon” was incorporated into the structure of CF. Under appropriate conditions an ...

A radioimmunoassay procedure has been developed for the direct measurement of methotrexate (MTX) in plasma, serum, cerebrospinal fluid, or urine samples. The assay is sensitive to levels of at least 100 pg of MTX and is highly specific for MTX in the presence of folinic acid (citrovorum factor), folic acid, tetrahydrogolic acid, and other folate analogs and known metabolites. Results from this ...

Previous experiments from this Laboratory with C4-methanol demonstrated that the carbon of methanol becomes incorporated into the methyl group of choline in the rat (1). This observation has been confirmed by Arnstein (2). In a subsequent investigation carried out in this Laboratory with methanol doubly labeled in the methyl group with deuterium and C14, it was found that less than one-third of...