نتایج جستجو برای: leukocyte mycobacterium defect

تعداد نتایج: 173782  

Journal: :Journal of immunology 2012
Veronica Azcutia Michael Stefanidakis Naotake Tsuboi Tanya Mayadas Kevin J Croce Daiju Fukuda Masanori Aikawa Gail Newton Francis W Luscinskas

At sites of inflammation, endothelial adhesion molecules bind leukocytes and transmit signals required for transendothelial migration (TEM). We previously reported that adhesive interactions between endothelial cell CD47 and leukocyte signal regulatory protein γ (SIRPγ) regulate human T cell TEM. The role of endothelial CD47 in T cell TEM in vivo, however, has not been explored. In this study, ...

Journal: :Lancet 2004
Saleh A Naser George Ghobrial Claudia Romero John F Valentine

BACKGROUND Crohn's disease, a form of inflammatory bowel disease, resembles some aspects of tuberculosis, leprosy, and paratuberculosis. The role of Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease is controversial. METHODS We tested for MAP by PCR and culture in buffy coat preparations from 28 individuals with Crohn's disease, nine with ulcerative colitis, and 15 with...

A Kamyabi F Soleimani H Eskandari

This study was performed to define the correlation between the level of consciousness based on Glasgow coma scale ( GCS), Glasgow outcome scale( GOS) and leukocyte count. Two hundred and thirty three patients ( female: 48, male: 185) ranged between 1-75 years old were studied. The results showed that there was a negative correlation between increasing leukocyte count and  GCS ( n=233.r= .0.3, p...

Journal: :iranian journal of immunology 0
behrouz gharesi-fard infertility research center rahil askarinejad-behbahani student research center, shiraz university of medical sciences, shiraz, iran shabnam behdin student research center, shiraz university of medical sciences, shiraz, iran

background: miscarriage is a common phenomenon complicating more than half of pregnancies. recurrent pregnancy loss (rpl) is defined as three or more pregnancies lost before the twentieth week of gestation. it is believed that abnormality in maternal immune reaction to fetus and sharing of hla antigens might be associated with rpl. objective: to investigate the effect of hla-drb1 sharing betwee...

2012
Sudhir Gupta Sudhanshu Agrawal Sastry Gollapudi

Primary selective IgM deficiency in adults is associated with normal T cell function, and patients clinically manifest with recurrent pyogenic bacterial infections. In this study, we present three patients with selective IgM deficiency with significant defects in T cells and NK cell cytotoxicity, and Mycobacterial avium intracellulare (MAC) infection. T cell defect is characterized by markedly ...

Journal: :Journal of immunology 2007
Diane Ordway Marcela Henao-Tamayo Marisa Harton Gopinath Palanisamy Jolynn Troudt Crystal Shanley Randall J Basaraba Ian M Orme

The HN878 strain of Mycobacterium tuberculosis is regarded as "hypervirulent" due to its rapid growth and reduced survival of infected mice when compared with other clinical isolates. This property has been ascribed due to an early increase in type I IFNs and a failure to generate TH1-mediated immunity, induced by a response to an unusual cell wall phenolic glycolipid expressed by the HN878 iso...

Journal: :The Journal of Experimental Medicine 2006
Timothy S. Olson Brian K. Reuter Kevin G-E. Scott Margaret A. Morris Xiao-Ming Wang Leslie N. Hancock Tracy L. Burcin Steven M. Cohn Peter B. Ernst Fabio Cominelli Jonathan B. Meddings Klaus Ley Theresa T. Pizarro

The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras to determine if SAMP ileitis results from a primary immunological defect or from dysregulated mucosal immunity secondary to intrinsic, nonhematopoietic (e.g., epithelial) dysfunction. SAMP mice receiving wild-type (AKR) BM dev...

2017
Felipe Fredes Jaime Pinto Nelson Pinto Pablo Rojas Daniel M Prevedello Ricardo L Carrau Thomas Schmidt

Background Reconstruction of surgical defects following cranial base surgery is challenging. Others have demonstrated that leukocyte-platelet-rich fibrin (L-PRF) stimulates tissue healing and bone regeneration. However, these studies have addressed mostly maxillofacial surgical wounds. Objective The objective of this study was to assess the possible adjuvant role of L-PRF in inducing neoossif...

Journal: :acta medica iranica 0
ali asghar hemmati department of pharmacology and toxicology, school of pharmacy, and physiology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran. and physiology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran. behnam ghorbanzadeh department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran. mohammad amin behmanesh department of histology, school of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran.

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...

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