نتایج جستجو برای: leukoencephalopathy

تعداد نتایج: 4847  

Journal: :Arquivos de neuro-psiquiatria 2014
Vera L Braatz Paulo José Lorenzoni Cláudia S K Kay Domingos C Chula Rosana H Scola Lineu C Werneck

A 39-year-old man presented with progressive headache, nauseas, blurriness and cortical blindness. Blood pressure: 230x140 mmHg. Glasgow score: 15. Fundoscopy revealed hypertensive retinopathy and papille de ma. Neurological examination was normal. Brain ma gnetic resonance imaging revealed area of swelling and high signal on FLAIR-weighted images on the brainstem and cerebral white-matter abno...

Journal: :Arquivos de neuro-psiquiatria 2008
Eliete Chiconelli Faria Juliana Harumi Arita Mirella Maccarini Peruchi Jaime Lin Marcelo Rodrigues Masruha Luiz Celso Pereira Vilanova

Division of Child Neurology / Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo SP, Brazil (UNIFESP-EPM): Resident, Department of Pediatrics, UNIFESP-EPM; Resident, Department of Radiology, Hospital Heliopolis, Sao Paulo SP, Brazil; Resident, Division of Child Neurology / Department of Neurology and Neurosurgery, UNIFESP-EPM; Associated Physician, Division of ...

Journal: :Orphanet journal of rare diseases 2018
Anna Ardissone Davide Tonduti Andrea Legati Eleonora Lamantea Rita Barone Imen Dorboz Odile Boespflug-Tanguy Gabriella Nebbia Marco Maggioni Barbara Garavaglia Isabella Moroni Laura Farina Anna Pichiecchio Simona Orcesi Luisa Chiapparini Daniele Ghezzi

BACKGROUND KARS encodes lysyl- transfer ribonucleic acid (tRNA) synthetase, which catalyzes the aminoacylation of tRNA-Lys in the cytoplasm and mitochondria. Eleven families/sporadic patients and 16 different mutations in KARS have been reported to date. The associated clinical phenotype is heterogeneous ranging from early onset encephalopathy to isolated peripheral neuropathy or nonsyndromic h...

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014
Deepa Bhojwani Noah D Sabin Deqing Pei Jun J Yang Raja B Khan John C Panetta Kevin R Krull Hiroto Inaba Jeffrey E Rubnitz Monika L Metzger Scott C Howard Raul C Ribeiro Cheng Cheng Wilburn E Reddick Sima Jeha John T Sandlund William E Evans Ching-Hon Pui Mary V Relling

PURPOSE Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on safety of intrathecal and high-dose MTX rechallenge in patients with neurotoxicity. PATIENTS AND M...

1965
Laura Adang Joseph Berger

Before embarking on experimental therapies for progressive multifocal leukoencephalopathy (PML), the diagnosis needs to be unequivocally established. Improving the underlying immunodeficiency state is the best initial approach to the management of PML. Immunosuppressive therapies should be discontinued when feasible. In the patient with AIDS, highly active antiretroviral therapy should be admin...

Journal: :Revista da Sociedade Brasileira de Medicina Tropical 2021

Journal: :Journal of Neurology, Neurosurgery & Psychiatry 1999

2012
Martina Troppmann Roland Büttner Michael Boewer Bernd Salzberger

INTRODUCTION Progressive multifocal leukoencephalopathy is an opportunistic infection occurring in patients with severe cellular immunodeficiency. This case highlights the role of cellular immunodeficiency in the reactivation of John Cunningham virus in a case of an early stage plasmacytoma. CASE PRESENTATION A 76-year-old Caucasian woman presented with progressive left-sided hemiparesis, acc...

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