Risk-reducing bilateral salpingo-oophorectomy (RRBSO) and risk-reducing mastectomy are widely used for BRCA1 and BRCA2 mutation carriers to reduce the risk of ovarian and breast cancer. To our knowledge, no risk-reduction therapy has addressed the BCRA1/2 carrier lifetime risk of intra-abdominal peritoneal carcinoma from an appendix source. We identified a BRCA1 carrier in a hereditary breast a...

PURPOSE Neonates with necrotizing enterocolitis (NEC) receive numerous radiologic investigations that potentially increase their lifetime cancer mortality risk. We evaluated our radiologic practice pattern for patients with NEC and estimated cumulative radiation exposure and lifetime cancer risk. METHODS Infants with NEC in a tertiary care NICU had patient demographics, imaging, treatments/in...

Lung cancer remains one of the commonest malignancies, accounting for 20% of all cancers in men with a lifetime risk of 1 in 13 and 12% of all cancers in women with a lifetime risk of 1 in 23 [1]. In the United Kingdom roughly 40,000 new cases are recorded each year. The estimated incidence for lung cancer in males in 2005 in the United States was 92,305 with approximately 91,537 males expected...

Objective To estimate the cumulative radiation exposure and lifetime attributable risk of cancer incidence associated with lung cancer screening using annual low dose computed tomography (CT).Design Secondary analysis of data from a lung cancer screening trial and risk-benefit analysis.Setting 10 year, non-randomised, single centre, low dose CT, lung cancer screening trial (COSMOS study) which ...

accounts for 27% of all cancers. according to the national cancer institutes' reports, the risk of breast cancer among american women is 13%. the current study aims to evaluate the level of risk perception of breast cancer and to identify its related factors amongst female employees. methods: this project was a cross-sectional study and participants were female employees working in hospitals an...

Oral cancer screening provides an opportunity for early detection and for education to high-risk tobacco and alcohol users. To plan interventions that would motivate oral cancer screening and risk reduction, we surveyed oral cancer risk perception and risk behaviors among participants in a free oral-cancer screening. Participants (N = 803) were racially diverse; 43% had a history of smoking and...

How much radiation does it take to cause our risk for an observable health effect to increase? Is there a level of radiation that is safe? How is radiation beneficial? The question of an effect occurring because of radiation exposure and the question of whether low‐ level radiation is safe are much‐debated topics. There are many thoughts on the answers to these questions, and suggested answers ...