Rho family GTPases play roles in cytoskeletal organization and cellular transformation. Tiam1 is a member of the Dbl family of guanine nucleotide exchange factors that activate Rho family GTPases. These exchange factors have in common a catalytic Dbl homology and adjacent pleckstrin homology domain. Previous structural studies suggest that the pleckstrin domain, a putative phosphoinositide-bind...

Since our discovery of the catalytic reduction of dinitrogen to ammonia at a single molybdenum center, we have embarked on a variety of studies designed to further understand this complex reaction cycle. These include studies of both individual reaction steps and of ligand variations. An important step in the reaction sequence is exchange of ammonia for dinitrogen in neutral molybdenum(III) com...

Anthraniloyl hydrazones contains one free -NH2 group attached to the aromatic ring and the other is the hydrazinic –Nitrogen. The H-NMR and D2O exchange studies inferred that the amide N-C=O and phenolic –OH are involved in hydrogen bonding. The mass spectrum of the ligand shows dimer peak. The anthranil hydrazides possesses antioxidant activity and also some of the hydrazone ligands are used i...

The introduction of a triazole-based ligand to the zeolitic imidazolate framework-7 via a postsynthetic ligand exchange strategy not only maintains its framework, high stability and morphology, but also provides extra uncoordinated nitrogen atoms to improve the π-π and Lewis acid-base interactions.

Cellular retinaldehyde-binding protein (CRALBP) is an essential protein in the human visual cycle without a known three-dimensional structure. Previous studies associate retinal pathologies to specific mutations in the CRALBP protein. Here we use homology modeling and molecular dynamics methods to investigate the structural mechanisms by which CRALBP functions in the visual cycle. We have const...

The all-inorganic nature of CsPbI3 perovskites allows to enhance stability in perovskite devices. Research efforts have led improved the black phase films; however, these strategies-including strain and doping-are based on organic-ligand-capped perovskites, which prevent from forming close-packed quantum dot (QD) solids necessary achieve high charge thermal transport. We developed an inorganic ...

ABSTRACT. The azo ligand obtained from the diazotization reaction of 2-aminobenzothiazole and 4-nitroaniline yielded a novel series complexes with Co(II), Ni(II), Cu(II), Zn(II) ions. were investigated using spectral techniques such as UV-Vis, FT-IR, 1H 13C NMR spectroscopic analyses, LC-MS atomic absorption spectrometry, electrical conductivity, magnetic susceptibility. molar ratio synthesized...

The pathogenic bacterium Aeromonas hydrophila has been shown to exclusively utilize a ligand exchange mechanism for siderophore-mediated iron uptake, with a single nonspecifi c siderophore receptor facilitating iron exchange. However, the genes involved in this process, including the gene encoding the nonspecifi c receptor, are unknown. Here we identify and characterize a novel gene, nsr1, from...

By nature of conducting ions, transporting substrates and transducing signals, membrane channels, transporters and receptors are expected to exhibit intrinsic conformational dynamics. It is therefore of great interest and importance to understand the various properties of conformational dynamics acquired by these proteins, for example, the relative population of states, exchange rate, conformat...

This paper illustrates the use of a kinetically controlled exchange reaction to effect regioselective modification of a hydrogen-bonded assembly. Both the bound anion and cation can control the exchange of ligand into the different layers of a synthetic G-quadruplex.