Regulation of neuronal calcium channels by GTP-binding proteins (G proteins) is likely to be an important mechanism by which inhibitory transmitters influence excitation-secretion coupling in presynaptic nerve endings. Here, we report that in peripheral sensory neurons from embryonic chick dorsal root ganglia (DRG), the G protein-mediated inhibition of voltage-dependent calcium channels may bes...

life traumatic experiences are major health problems in different communities. early trauma exposures such as physical and sexual abuse, and midlife traumatic events like exposing to disasters are predisposing and precipitating risk factors for many psychiatric disorders, although many people facing to trauma may not show any problematic symptoms and are quite resilient. neuropsychiatric eviden...

Recently, much attention has focused on the treatment of BPH with the pollen extract, Cernilton. The present investigation was designed to identify the active component in this agent which might be responsible for the symptomatic relief of BPH as previously reported. Sequential purification of the active component present in the pollen extract was carried out by a combination of dialysis, gel f...

Bacteriocin produced by Bacillus mycoides isolated from whey showed strong inhibition against food borne serious pathogens, Listeria monocytogenes and Leuconostoc mesenteroides. Antibacterial substance was partially purified by salt saturation method. Partially purified bacteriocin withstood temperature up to 100°C, found active at wider pH range (4 to 11) and was sensitive to trypsin. This inh...

A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder,...

A glutathione S-transferase (GST, EC 2.5.1.18) inhibitor was isolated from the onion bulb by fractionation and purification using Sep-pak Vac C18 column, TLC and HPLC. Five partially purified onion bulb GSTs (GSTa and GSTb as minor GSTs, and GSTc, GSTd and GSTe as dominant GSTs) separated by DEAE column were used to detect the inhibitory substance in onion bulb extract. Among the three fraction...

This study was initiated to characterize nonadrenergic-noncholinergic (NANC) inhibitory neurotransmission in penile corpus cavernosum. Using organ baths, isometric tension measurements were made in strips ofhuman and rabbit corpus cavernosum. In examining endothelium-mediated responses, cumulative additions of exogenous acetylcholine elicited dose-dependent relaxations which were significantly ...

zataria multiflora boiss. is used in iranian traditional medicine to treat gastrointestinal disorders and menrrhalgia. the inhibitory effect of this herb on rat ileum contractions is also reported. the aim of this study was to investigate the effect of zataria multiflora boiss. hydroalcoholic leaf extract (zhle) on isolated rat uterus in presence of some known uterus stimulants. pieces of virgi...