The genome is constantly exposed to exogenous DNA damaging events in the form of radiation, viral infection and chemicals. Endogenous processes such as DNA replication and free radical formation also threaten the integrity of the genome. DNA damage is directly deleterious to cells and also promotes tumorigenesis. Eukaryotic organisms have evolved a signaling pathway, called the DNA damage respo...

•Extensive changes in the chromatin-bound proteome occur upon DNA damage•Histones and RNA polymerases are lost while repair Ub-ligases increase•Ub-ligases needed for chromatin expansion increased locus mobility•Loss of Ufd4-driven ectopic dynamics impairs strand invasion Eukaryotic cells package their genomes around histone octamers. In response to damage, checkpoint activation yeast induces co...

in this paper, we consider a cooperative cognitive radio network in which there is an ofdm primary link and multiple single carrier secondary links.the primary link is required to maintain its secrecy rate above a predefined threshold. if the secrecy rate requirement is not satisfied, the secondary system help primary link to maintain its secrecy rate requirement. in doing so, the secondary trans...

in this paper, the capabilities of displacement curvature derived from static response data for finding the location and severity of damage in euler-bernoulli beams are assessed. static response of a beam is obtained using the finite element modeling. in order to reduce the number of measured nodal displacements, the beam deflection is fitted through a polynomial function using a limited number...

Modern imaging modalities, including magnetic resonance imaging (MRI), are valuable diagnostic and therapy monitoring tools in rheumatoid arthritis (RA). This article reviewed how these imaging modalities have greatly improved our understanding of pathogenic mechanisms in RA, namely the link between inflammation and damage. For example, traditional paradigms regarding the mechanisms of joint de...

Of three possible early biochemical changes which were investigated in rats after hyperoxia, one was shown to be a useful marker of damage in this species. Mitochondrial oxygen uptake measured in lung homogenates has already been reported to be impaired after 24 h. With a purified mitochondrial fraction, we found significant impairment after only 3 h exposure to 100% oxygen. To our knowledge, t...