This paper describes an operational system which can acquire the core meanings of words without any prior knowledge of either the category or meaning of any words it encounters. The system is given as input, a description of sequences of scenes along with sentences which describe the [EVENTS] taking place as those scenes unfold, and produces as output, a lexicon consisting of the category and m...

1. ABSTRACT In this paper we present a lightweight teamwork implementation through use of abstraction hierarchies. The basis of this implementation is ADAPT, which supports Autonomous Dynamic Agent Planning for Teamwork. ADAPT’s novelty stems from how it succinctly decomposes teamwork problems into two separate planners: a task network for the set of activities to be performed by a specific age...

In this study we develop a highly simplified simulation of diffusion through a structured society. By testing diffusion of a single arbitrary trait through different social network structures we show that the type of social network can significantly extend the time required for a population to reach consensus. This is especially true of small-world networks where conflict may persist far longer...

Riluzole, an inhibitor of glutamate release, has shown the ability to inhibit melanoma cell xenograft growth. A phase 0 clinical trial of riluzole as a single agent in patients with melanoma resulted in involution of tumors associated with inhibition of both the mitogen-activated protein kinase (MAPK) and phophoinositide-3-kinase/AKT (PI3K/AKT) pathways in 34% of patients. In the present study,...

Variants of unknown significance (VUS) complicate the assignment of risk to new DNA sequence variants found in at-risk populations. This study focused on the poorly studied linker region of the cancer-associated BRCA2 protein encoded by exons twelve through fourteen of BRCA2. To develop a new method to characterize VUS in this region of BRCA2, we first chose to study 4 reported VUS occurring on...

In this article, we describe a photosensitizer (PS) whose ability to generate singlet oxygen (1O2) and fluorescence emission has been designed as tumor responsive. More specifically, the PS consists of a silicon phthalocyanine (SiPc) core, axially substituted with two subphthalocyanine (SubPc) units, covalently linked by a disulfide linker, which is cleavable in the presence of a strong reducin...

In molecular electronics, the linker group, which attaches the functional molecular core to the electrode, plays a crucial role in determining the overall conductivity of the molecular junction. While much focus has been placed on optimizing molecular core conductivity, there have been relatively few attempts at designing optimal linker groups to metallic or semiconducting electrodes. The vast ...

Kinesin stepping is thought to involve both concerted conformational changes and diffusive movement, but the relative roles played by these two processes are not clear. The neck linker docking model is widely accepted in the field, but the remainder of the step--diffusion of the tethered head to the next binding site--is often assumed to occur rapidly with little mechanical resistance. Here, we...

An explicit formulation of the configuration-dependent potential energy function and the Brownian Dynamics (BD) algorithm used to simulate the chromatin polymer is detailed. For the readers’ convenience, this document provides a complete description of our methodology, and thus some of the material is redundant with that found in the Material and Methods section of Beard & Schlick (Structure wi...

Bacterial pathogens often employ two-component systems (TCSs), typically consisting of a sensor kinase and a response regulator, to control expression of a set of virulence genes in response to changing host environments. In Staphylococcus aureus, the SaeRS TCS is essential for in vivo survival of the bacterium. The intramembrane-sensing histidine kinase SaeS contains, along with a C-terminal k...