Aim: To evaluate in vitro hepatoprotective activity of ethanolic extract from Corchorus depressus (CDEE) against CCl4 induced toxicity in HepG2 cell line. Methods: In vitro cytotoxicity and hepatoprotective potential of CDEE were evaluated using HepG2 cells. Based on the cytotoxicity assay, CDEE (50, 100, 200 mg/ml) was assessed for hepatoprotective potential against CCl4 induced toxicity by mo...

Background Traditionally, the plant was used for various diseases, including neuronal disorders. To evaluate neuroprotective activity of Hibiscus vitifolius L. against Colchicine induced Alzheimer’s disease in rat model. Method Neuroprotective carried out by on Sprague-Dawley rats. cerebrum colchicine lesion. The behavioural assessments such as locomotor activity, spatial navigation task, open ...

INTRODUCTION Radioiodine (131I) therapy is widely accepted as an essential part of therapeutic regimens in many cases of differentiated thyroid cancer. Radiation-induced oxidative damage to macromolecules is a well known phenomenon. Frequently examined process to evaluate oxidative damage to macromolecules is lipid peroxidation (LPO), resulting from oxidative damage to membrane lipids. The aim ...

Aim The aim of this study was to examine the potential ameliorative effects caffeic acid (CA) on hydrogen peroxide (H2O2)-induced neurodegeneration in a human SH-SY5Y cell line, as well possible mechanisms involved. Method Cell proliferation evaluated by WST-1 assay. apoptotic index calculated TUNEL Assay. Antioxidant parameters were studied measuring reactive oxygen species (ROS), lipid peroxi...

Eugenia jambolana (Jamun) fruit has been reported to give soothing effect on human digestive system. Present study includes the effect of ethanolic extract of seeds of E. jambolana (EJE) against gastric ulcers induced by 2 h cold restraint stress (CRS), aspirin (ASP, 200 mg/kg, 4 h), 95% ethanol (EtOH, 1 ml/200 g, 1 h) and 4 h pylorus ligation (PL) in rats. To ascertain the mechanism of action ...

BACKGROUND Oxidative stress enhances lipid peroxidation (LPO), which both are implicated in the promotion and progression stages of carcinogenesis, in particular under conditions of chronic inflammation and infections. Exocyclic etheno-DNA adducts, which are formed by LPO-products such as 4-hydroxy -2-nonenal, are strongly pro-mutagenic DNA lesions. METHODS The development of ultra-sensitive ...

INTRODUCTION Lipid peroxidation (LPO) results from oxidative damage to membrane lipids. Whereas LPO rises in normal pregnancy, the effect of gestational diabetes mellitus (GDM) on this process has not been clearly defined. MATERIALS AND METHOD Fasting blood concentrations of malondialdehyde+4-hydroxyalkenals (MDA+4-HDA), as LPO index, TNFa soluble receptors (sTNF-R1 and sTNF-R2), and soluble ...

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein...

Oxidation is very essential to many living organisms for the production of energy fuel biological processes. The free radicals and other reactive oxygen species (ROS), which are continuously, produced in vivo, responsible oxidation. aim present study was investigate vitro vivo antioxidant potential ethanolic extraction justicia gendarussa burm leaves [EEJG]. done by using various In methods suc...

BACKGROUND Bacterial meningitis is often associated with cerebral compromise which may be responsible for neurological sequelae in nearly half of the survivors. Little is known about the mechanisms of CNS involvement in bacterial meningitis. Several studies have provided substantial evidence for the key role of nitric oxide (NO) and reactive oxygen species in the complex pathophysiology of bact...