To clarify the alternative mechanisms to vitamin E (VE) regulating lipid peroxide accumulation in the liver after docosahexaenoic acid (DHA) ingestion, we examined the relationship between the DHA-induced lipid peroxide formation and induction of the xenobiotic transporters, Ral-binding GTPase-activating protein (RalBP1) and multidrug resistance-associated proteins 1, 2 and 3 (MRP1-3), in the l...

lipid oxidation has adverse effect on food deterioration and human health. the antioxidant activity of fennel seed extracts (fse) was evaluated by synthetic antioxidant. its oxidative stability was compared in olive oils in concentrations of bha (75 ppm), bht(75 ppm) and  1:1 bha to bht ratio. peroxide (pv), p-anisidine (av) and totox values were evaluated to assess the extent of oil deteriorat...

Erythrocytes from normal subjects and from cases of sickle cell disease were exposed to hydrogen peroxide and the extent of membrane lipid peroxidation studied. Significantly increased peroxidation was observed in intact erythrocytes, isolated lipids from intact erythrocytes or their ghosts compared with normal controls. However, the extent of lipid peroxidation was less for isolated lipids of ...

Studies of ferriheme cyclooxygenase, using two different assay systems, show that a variety of peroxides can trigger a rapid acceleration of cyclooxygenase activity to produce prostaglandins. Lipid hydroperoxides formed by lipoxygenase were the most potent activators tested, followed by prostaglandin Gz, which was slightly less potent. Peroxides nonspecifically generated during arachidonate aut...