Objective: To explore anticancer agents from Cuminum cyminum against hepatocellular carcinoma.Study Design: In-silico approaches using computational tools to determine the potential of phytoconstituents cumin carcinoma.Place and Duration Study: This study was conducted May 2021 January 2022 at Department Bioinformatics Biosciences Capital University Science Technology, Islamabad, Pakistan.Mater...

The aims of the present study were to identify the compounds responsible for the anti-malarial activity of Dacryoedes edulis (Burseraceae) and to investigate their suitability as leads for the treatment of drug resistant malaria. Five compounds were isolated from ethyl acetate and hexane extracts of D. edulis stem bark and tested against 3D7 (chloroquine-susceptible) and Dd2 (multidrug-resistan...

Comparative assessment of in vitro and in vivo biological activity of anthracene-derived aminophosphonates, bis-aminophosphonates and poly(aminophosphonate)s, namely poly(oxyethylene aminophosphonate)s (4,5) and poly[oxyethylene aminophosphonate-co-H-phosphonate)]s, (6,7), were carried out in order to establish their value as potential drug candidates. The compounds were tested for in vitro cyt...

Protein-protein interactions (PPIs) play a central role in most biological processes, and therefore represent an important class of targets for therapeutic development. However, disrupting PPIs using small-molecule inhibitors (SMIs) is challenging and often deemed as "undruggable." We developed a cell-based functional assay for high-throughput screening to identify SMIs for steroid receptor coa...

O presente trabalho reuniu na literatura estudos acerca das atividades biológicas da Schinus terebinthifolius e avaliou possíveis características físico-químicas, farmacocinéticas de toxicidade moléculas isoladas desta espécie. Inicialmente, se realizou uma ampla revisão literatura, por meio bases dados: Google Acadêmico, Portal Periódicos Capes, SciELO PubMed, com os descritores: “Schinus Radd...

Objective: To explore the possibility of obtaining effective and harmless antibacterial drugs by conventional synthesis new piperidine analogs. Methods: The target compound was carried out cyclization reaction involving aromatic aldehydes amine further evaluated for their antimicrobiological assay using agar disc diffusion method. Computational investigation such as density functional theory (D...

Abstract Aim This study outlines an efficient weighted network centrality measure approach and its application in pharmacology for exploring mechanisms of action the Ruellia prostrata (RP) bignoniiflora (RB) herbal formula treating rheumatoid arthritis. Method In our proposed method we first calculated interconnectivity scores all targets then computed score to identify major based on score. We...

Background: The novel coronavirus (2019-nCoV) causes a severe respiratory illness unknown to human before. Its alarmingly quick transmission many countries across the world has resulted in global health emergency. Therefore, an imminent need for drugs combat this disease been increased. Worldwide collaborative efforts from scientists are underway determine therapy treat COVID-19 infections and ...

On-going global pandemic COVID-19 has spread all over the world and led to more than 1.97 million deaths till date. Natural compounds may be useful protecting health in this perilous condition. Mechanism of shuttle entry SARS-COV-2 virus is by interaction with viral spike protein human angiotensin-converting enzyme-2 (ACE-2) receptor. To explore potential natural therapeutics, 213 important phy...

Cisplatin, doxorubicin, hydroxycamptothecin, leucovorin, vincristine and 5-fluorouracil resistance of cancer cells are associated with the activities C-Jun N-Terminal Kinase 1 (JNK1). Inhibition JNK1 by pharmacological agents could be a beneficial attempt for reversing chemoresistance various cells. However, there is no FDA-approved JNK inhibitor safe use in clinics today’s clinics. In this stu...