Treatment of malignant gliomas represents one of the most formidable challenges in oncology. The combination of surgery, radiation, and chemotherapy yields median survivals of less than one year. Here we demonstrate the use of a minimally invasive surgical technique, convection-enhanced delivery (CED), for local administration of a novel nanoparticle liposome containing topotecan. CED of this l...

Achievement of potent immunoresponses against self/tumor antigens and effective therapeutic outcome against advanced tumors remain major challenges in cancer immunotherapy. The specificity and efficiency of two nanoparticle-based delivery systems, lipid-calcium-phosphate (LCP) nanoparticle (NP) and liposome-protamine-hyaluronic acid (LPH) NP, provide us an opportunity to address both challenges...

Numerous targeted nanotherapeutics have been described for potential treatment of solid tumors. Although attention has focused on antigen selection and molecular design of these systems, there has been comparatively little study of how cellular heterogeneity influences interaction of targeted nanoparticles with tumor cells. Antigens, such as HER2/ERBB2, are heterogeneously expressed across diff...

These precursor nanoparticles were collected off-chip and were irradiated with ultraviolet (UV) light in bulk to polymerize the nanoparticle interiors into hydrogel cores. Multi-angle laser light scattering in conjunction with asymmetric flow field-flow fractionation was used to Figure 1: Numerical simulations show the mixing of water and isopropyl alcohol in a microfluidic device. The alcohol,...

Incorporation of membrane proteins into reconstituted lipid membranes is a common approach for studying their structure and function relationship in native-like environment. In this work, we investigated fluorescence properties liposome-reconstituted major light-harvesting complexes plants (LHCII). By utilizing liposome labelling with the fluorescent dye molecules single-molecule microscopy tec...