The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were ...

Sintering of metal powders is a well-established industrial process for specific applications, which allow a cheap series production of metal parts even with complex shape. The residual porosity, always present in sintered power compacts, limits their mechanical strength. On the other hand, for several products such porosity is needed. Products of that kind are for example: metal filters showin...

Metallic bone implants possess numerous problems limiting their long-term efficacy, such as poor prolonged osseointegration, stress shielding, and corrosion under in vivo environments. Such problems are compounded for bone cancer patients since numerous patients receive orthopedic implants after cancerous bone resection. Unfortunately, current orthopedic materials were not originally developed ...

Polysaccharides are suitable for application as hydrophilic matrices because of their ability to hydrate and swell upon contact with fluids, forming a gel layer which controls drug release. When extracted from plants, polysaccharides often contain significant quantities of starch that impacts upon their functional properties. This study aimed to evaluate differences in swelling, erosion and dru...

Abstract: Background: Artemether is a potent antimalarial drug used in the first-line treatment of multi-drug-resistant malaria. It belongs to BCS II, exist different polymorphic forms, and exhibits incomplete absorption low oral bioavailability owing poor dissolution. Aim: The present study evaluates effect mesoporous materials liquisolid compact for augmentation dissolution drug, stability. M...

This program generates a single search tree, compacts it to reduce memory/disk space, then utilizes it to very quickly generate valid paths in an 8-connected gridworld. This technique is similar in principle to RRTs used in robotics.