background: the general pattern of epidemiologic transition from communicable to non-communicable diseases is also observed for gastrointestinal and liver diseases (gild), which constitute a heterogeneous array of causes of death and disability. we aimed to describe the trend of gild in iran based on the global burden of disease (gbd2010) study from 1990 to 2010. methods: the trend of number of...

BACKGROUND Liver cancer is a common cancer with poor prognosis in China. In this study, the national population-based cancer registration data were used to evaluate and analyze liver cancer incidence and mortality in China in 2011 and provide a reference for liver cancer prevention and control. METHODS We collected and evaluated the incidence and mortality data of liver cancer in 2011 from 17...

background : transarterial chemoembolization is the preferred treatment for unresectable, intermediate-stage hepatocellular carcinoma. survival after transarterial chemoembolization can be highly variable. the purpose of this study is to identify the factors that predict overall survival of patients with unresectable hepatocellular carcinoma who undergo transarterial chemoembolization as the in...

BACKGROUND AND AIMS The National Cancer Screening Program (NCSP) for liver cancer was initiated in 2003 in Korea. The objective of this study was to evaluate the participation rate of the program and to provide preliminary information on its results based on data collected by the NCSP in 2009. METHODS The target population of the NCSP for liver cancer in 2009 was comprised of 373,590 adults a...

BACKGROUND Primary liver progenitor cell cancer is a rare disease entity. Current nomenclature of primary liver cancer with prominent progenitor features is not comprehensive. This study was aimed to investigate the existence of this type of primary liver cancer and characterize it immunohistopathologically based on the emerging understanding of cancer stem cell pathobiology. METHODS Surgical...

Xanthohumol may prevent and cure diabetes and atherosis, have oxidation resistance and antiviral function as well as anticancer effect preventing cancer cell metastasis. We investigate whether the anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-κB/p53-apoptosis signaling pathway. Human liver cancer HepG2 cell were treated with 10, 20, 30...

The development of liver cancer would undergo a sequential progression from chronic inflammatory liver disease, cirrhosis to neoplasia. During these pathophysiological changes, abnormal liver microenvironment might induce the hepatocytes to die, abnormally proliferate and initiate cancer stem cells. Metallocarboxypeptidases (MCPs) involved in multiple biological functions including inflammation...

The invasiveness and low survivability on the part of patients associated with cancer continues to raise global concern. Different approaches have been used in treatment restoration normalcy patients. However, most therapeutic strategies employed are challenged high cost, efficacy, toxicity, multiple side effects. In recent times, emergent studies provided evidence that functional foods their b...

The incidence of liver cirrhosis and pancreatic cancer varies between countries stands out as an important health problem worldwide. Liver is the most advanced stage chronic disease a widespread result damage. etiology cancer, which are major causes fatalities in developed countries, poorly understood. Many metabolic physiological processes human body utilize trace elements. creation developmen...