We investigated the effect of an albumin infusion on enzyme activity, expression level cytochrome P450 2E1 (CYP2E1), and oxidative stress in serum liver streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced alanine aminotransferase aspartate activities rat compared with those untreated Treatment elevated catalytic activity CYP2E1, stress, decreased reducing potentials liver, su...

Acetyl-CoA synthetase (AceCS), which catalyzes the activation of acetate to produce acetyl-CoA, was found to have a much greater Km value for acetate in liver mitochondria than that in the heart mitochondria of rats, indicating that two different types of AceCS are located in the liver and heart mitochodria. Recently, Fujino et al. reported that mouse heart mitochondrial AceCS, designated AceCS...

Hyperglycemia in Diabetes mellitus (DM) induces oxidative stress and mitochondrial disruptions the liver, thereby triggering apoptosis through Bcl-2 family signaling. Excessive leads to liver dysfunction. Chlorogenic acid (CGA) was elucidated this study preventing dysfunction as a progression of DM. The diabetic model conducted Wistar rats, divided into six groups. Blood examinations were done ...

A significant decrease of hepatic high-Km glucose- phosphorylating enzyme glucokinase (ATP- D- glucose 6- phosphotransferase, EC 2.7. 1.2, GK) and low-Km hexokinases (EC 2.7. 1.1. HK) activities were noticed in liver treated with 2, 2'- dichlorodiethyl sulfide (sulfur mustard, HD) when injectedinteraperitoneally to male rats in 114 LD50. This decrease occurred 1.5 to 5.5 hours after the in...

Olives and olive oil contain large amounts of oleuropein. This phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. Thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...