objective(s): to appraise the antihepatotoxic efficacy of ethanolic extract of operculum turpethum root on the liver of swiss albino mice.   materials and methods:   hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of n-nitrosodimethylamine (ndma) at the concentration of 10 mg/kg body weight. the liver toxicity and therapeutic effect of the plant et...

Introduction: One of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. Aspirin (ASA) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. The aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...

liver injury occurs with many drugs; therefore, a thorough work up is important for establishing the diagnosis. we report a case of trifluoperazine-induced cholestatic jaundice. a 44-year old male with schizoaffective disorder developed an increase in liver enzymes and jaundice after starting treatment with trifluoperazine. workup for other potential etiologies was negative.

The tRNA methyltransferases from normal rat liver and Novikoff hepatoma have been compared with respect to their base specificity, capacity to methylate, and reaction kinetics, using mixed Escherichia coli B transfer RNA (tRNA) and ethionine-induced partially methyl-deficient rat liver tRNA. The pattern of base methylation of the two substrates is different with the use of enzymes from either s...

The purpose of this study was to examine the acute and sub-acute effects of diazinon onhistopathological parameters of liver tissue and blood level of hepatic enzymes of male commonfrog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or oneweek. Hepatic enzymes containi...

background: non-alcoholic fatty liver disease (nafld) is characterized by macro vesicular steatosis in the absence of alcohol. patients with (nafld)need extensive education and support in their treatment. our aim was to investigate the effect of telenursing on liver enzymes (alt and ast) in patients with nafld. methods: our study is a randomized controlled clinical trial. in this study, 60 pati...

The present study examined the antioxidant defense of glutamine on plasma and liver antioxidant status in broilers under PHS with respect to changes in the levels of lipid peroxidation marker malondialdehyde (MDA), total antioxidant status (TAS) and the activities of anti peroxidative enzymes [superoxide dismutase (SOD) and glutathione dependent antioxidant enzymes glutathione peroxidase (GPX)]...