BACKGROUND Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been strongly implicated in the pathogenesis of many types of human cancer. We wanted to specifically define their role in established colorectal cancer liver metastases. PATIENTS AND METHODS The MMP/TIMP expression profiles of N=9 colorectal primary tumour liver metastasis tissue pairs were determined using ...

PURPOSE The liver is the most common site of systemic metastases from uveal melanoma (UM). Such metastases usually continue to develop despite the application of current treatment modalities. This study was conducted to obtain insight into the molecular pathways that underlie the development of UM metastasis and thus to identify potential novel therapeutic pathways for this disease. METHODS M...

Herein, we report a rare case in which bisphosphonate zoledronic acid (ZA) effectively treated not only multiple bone metastases but also lung, pleural and liver metastases from renal cell carcinoma (RCC). Recently, ZA is used to treat skeletal-related events (SREs) such as bone pain caused by bone metastasis from many kinds of cancer. The patient in the present report had multiple bone metasta...

Each year in the UK, between 1214 000 people develop liver metastases from colorectal cancer. These metastases will contribute to the death ofthe patient in about 80% ofcases. Treatments aimed at these tumours are best administered when the tumour is small. Current investigative methods allow tumours as small as 0.5 mm to be detected, and should be offered to all colorectal cancer patients at r...

Abstract Introduction Liver resection offers the best curative treatment for hepatic metastases secondary to colorectal (CR) cancer. The aim of this study was compare survival outcomes between patients having liver once (OR) versus those redo-liver (RR) metastases. Methods This a retrospective done on 171 who underwent (97 had OR & 74 RR) from January 2009 2020 across East Midlands hospital...

Thermal ablation has been considered as an alternative for local curative intent in patients with unresectable colorectal liver metastases. The influence of primary tumor location on the prognosis of colorectal liver metastases patients who have undergone microwave ablation has yet to be determined. We reviewed 295 patients who underwent microwave ablation for colorectal liver metastases at our...

Insulinoma liver metastases are rare because only a minority of insulinomas (10%) is malignant. We report a case of a 54 year-old patient diagnosed with malignant insulinoma with synchronous liver metastases, treated first by systemic chemotherapy by Streptozotocin and 5-Fluorouracil without clinical control of symptoms (hypoglycemia), then by pancreatic resection and seven chemoembolization wi...

BACKGROUND The purpose of the study was to evaluate the value of diffusion-weighted imaging in the differential diagnosis of haemangiomas from metastases of the liver. PATIENTS AND METHODS.: We analyzed 69 lesions in 38 patients (33 haemangiomas; 36 metastases) in the retrospective study. Diffusion-weighted imaging was performed using a breath-hold single-shot echo-planar spin echo sequence wi...

BACKGROUND Despite major advances in therapies for liver metastases, colorectal cancer remains one of the commonest causes of cancer-related deaths in the UK. SOURCES OF DATA The international literature on the management of colorectal liver metastases (CLM) was reviewed. AREAS OF AGREEMENT Due to a combination of highly active systemic agents and low perioperative mortality achieved by hig...