The present study aims at investigating the determinants of the undesirable aggravation of liver steatosis observed in rats first deprived, for 7 months from the 6 th week after birth onwards, of a dietary supply of long-chain polyunsaturated 3 fatty acids by exposure to a 5% sunflower oil-containing diet and then given access for about 2 weeks to the same diet enriched with 5% flaxseed oil in ...

Some groups of male Sprague-Dawley rats were fed a diet containing either 28% beef fat and 2% corn oil or 30% corn oil (high fat), and others were fed either 13% beef fat and 2% corn oil or 15% corn oil (moderate fat), for varying periods of time, with or without exposure to aflatoxin B, (AFBi). Assays for hepatic microsomal oxidases [p-nitroanisole demethylase and benzo(a)pyrene hydroxylase] w...

The present communication records the first of a series of experiments begun at the suggestion of Professor E. V. McCollum on the chemical examination of antirachitic substances. The most familiar of these substances occurs in cod liver oil, and is commonly known as the antirachitic vitamin, or vitamin D. The cod liver oil which I used was an unfrozen, unadulterated oil, rendered at Bay Bulls, ...

Fish oil supplementation and physical exercise may induce oxidative stress. We tested the effects of 8 wk of alpha-tocopherol (vitamin E) and fish oil (FO) supplementation on resting and exercise-induced oxidative stress. Rats (n = 80) were divided into groups supplemented with FO, FO and vitamin E (FOVE), soy oil (SO), and SO and vitamin E (SOVE), and for FOVE and SOVE they were divided into c...

Introduction Vitamin D was first isolated from tuna fish oil in 1936, and synthesized in 1952. It is a prohormone sterol which the body manufactures, given sunlight, from 7-dehydrocholesterol. Vitamin D3 (C27H44O, cholecalciferol) is the form we and other animals make, and what is found in fish liver oil. Oddly enough, fish cannot synthesize vitamin D. They get theirs low on the food chain from...

objective(s):  protective effects of different extracts and essential oil from pimpinella anisum           l. seeds were examined against carbon tetrachloride (ccl4)-induced toxicity. the parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. in the in...

Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) exert health benefits which are dependent upon their incorporation into blood, cells and tissues. Plasma and tissue deposition of LC n-3 PUFA from oils extracted from the micro-algae Nannochloropsis oculata and from krill were compared in rats. The algal oil provides eicosapentaenoic acid (EPA) partly conjugated (15%) to phospholipids...

Uncoupling protein 2 (UCP2) is a possible target molecule for energy dissipation. Many dietary fats, including safflower oil and lard, induce obesity in C57BL/6 mice, whereas fish oil does not. Fish oil increases UCP2 expression in hepatocytes and may enhance UCP2 activity by activating the UCP2 molecule or altering the lipid bilayer environment. To examine the role of liver UCP2 in obesity, we...

Rat pups deficient in n-3 fatty acids received an oral administration of docosahexaenoic acid (DHA)-rich, eicosapentaenoic acid (EPA)-free microalgal oil (DMO) or fish oil (FO). DMO administration almost restored liver EPA to the level of the control diet-fed dam's pups, but FO administration did not. This suggests that EPA could be recovered in the liver, even though EPA-free DMO was supplemen...

In numerous in vivo systems it has been shown that diets high in menhaden oil (a fish oil high in omega-3 fatty acids) can inhibit the carcinogenic process. In the present study, we have assessed the effects of a diet containing menhaden oil on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA adduct formation in target tissues of the male Fischer 344 rat. Young adult male Fischer 344 rats were ...