Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions. During starvation, autophagy is induced in numerous organisms ranging from yeast to mammals, and promotes survival by supplying nutrients and energy. In the early neonatal period, when transplacental nutrients supply is interrupted, s...

OBJECTIVE To study the carbon tetrachloride-induced hepatoprotective activity in cow urine. METHODS Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Sil...

Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As2O3)-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As2O3-induced liver injury in rats. Male Wistar ra...

BACKGROUND Liver transplantation is so far the most effective therapeutic modality for end-stage liver diseases, but ischemia/reperfusion (I/R) injury represents a critical barrier to liver transplantation. Primary graft dysfunction and small-for-size syndrome are closely associated with I/R injury. Ischemic preconditioning (IPC) is defined as a brief period of liver ischemia followed by reperf...

The aim of the present study was to examine potential protective effects of methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a rat model of acute intoxication with carbon tetrachloride (CCl4) by tracking the changes in liver morphology and function. Serum transaminase and bilirubin were significantly elevated in animals treated with CCl4 alone. A pretreatment with M and...

objective: pseudomonas aeruginosa is the major cause of septicemia and wound infection in burned patients. immunotraphy is the best practical way for prevention and treatment of these infections. flagella as one of the most important bacterial virulence factors has important role in attachment, motility, chemotaxis and tlr-5-dependent immune response so that it propounded as a vaccine candidate...

many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. no systematic study has been done on protective efficacy of capparis spinosa (capparidaceae) to treat hepatic diseases. protective action of c. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was in...

Abstract Liver diseases is a dynamic pathological condition which can be slowed down in its initial phases without proper clinical management of fibrosis Progressive liver damage may lead to cirrhosis and ultimately failure or primary cancer are irreversible conditions. In order cure fibrotic liver, early stages should the center attention. Some supplements complementary alternative medicine (C...

Liver is considered to be one of the vital organs which helps in maintaining the health of body. Yakrit (liver) is being described right from the vedic period. Modern lifestyles can overstress the liver and make it malfunctioning. No significant and safe hepato-protective drugs are available in modern therapeutics. The nature has bestowed some plants with the property to prevent, treat and cure...