نتایج جستجو برای: local administration
تعداد نتایج: 754535 فیلتر نتایج به سال:
Parenteral and oral routes have been the traditional methods of administering cytotoxic agents to cancer patients. Unfortunately, the maximum potential effect of these cytotoxic agents has been limited because of systemic toxicity and poor tumor perfusion. In an attempt to improve the efficacy of cytotoxic agents while mitigating their side effects, we have developed modalities for the localize...
Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochl...
The article explore three issues: 1) How widespread and important are various forms of transnational organizational innovation in the Danish public sector? 2) How are these organizational innovations related to each other? 3) What are the differences and similarities in transnational organizational innovation between state administration and local government and how can they be explained? By tr...
Introduction: Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examines the possibility that effective anti rheumatic treatment will decrease the level of synovial citrullination. Methods: Synovial biopsies were obtained from 11 rheumatoid ar...
PURPOSE To assess the possibility of promoting esophageal squamous cell carcinoma after direct administration of diethylnitrosamine (DEN) into the wall of the esophagus. MATERIAL AND METHODS Adult male Wistar rats weighing 250-300 g were used in the studies. Via laparotomy, solution of DEN (at the volume of 0.1 ml) was injected directly into the esophageal wall. Animals were divided into 3 gr...
In this report we investigated local regulatory mechanisms in graft rejection and their response to local immunosuppressive therapy. For this purpose local immunosuppression was induced in rat kidney allografts by intrarenal infusion of prednisolone. Intrarenal drug delivery resulted in high drug levels within the graft and low systemic drug levels. Systemic drug levels were by themselves not s...
Local administration routes have been investigated to reduce the systemic toxicity and to increase the local efficacy of cytotoxic drugs. Some examples of local administration strategies are cutaneous, intraperitoneal, intrathecal and intravesical chemotherapy. When administered locally, high local drug concentrations can be achieved with increased local efficacy and, conditionally that only sm...
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