نتایج جستجو برای: local estrogen
تعداد نتایج: 573435 فیلتر نتایج به سال:
Background: Insulin resistance (IR) has been well studied in the initiation and development of endometrial endometrioid carcinoma (EEC). As yet, it has been largely neglected for estrogen sensitivity in local endometrium in hyperinsulinemia-induced systemic microenvironment. The aim of this study was to investigate the role of insulin in regulating estrogen sensitivity and explore the potential...
OBJECTIVES To investigate the effect of black cohosh on the estrogen biosynthesis in the breast in vitro. METHODS Steroid sulfatase (STS) activity was studied in normal breast tissue obtained from pre- and postmenopausal women undergoing reduction mammoplasty. STS protein expression was studied by immunohistochemistry and western blotting. Breast tissue was incubated in vitro without or with ...
Human CYP2A6, which is predominantly expressed in liver, is a key enzyme responsible for the metabolism of nicotine, coumarin, and some pharmaceutical drugs. CYP2A6 is also expressed in sex steroid-responsive tissues such as breast, ovary, uterus, testis, and adrenal grand. In this study, we examined the regulation of CYP2A6 gene by estrogen. Reverse transcription-polymerase chain reaction (RT-...
background: due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.the present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (bmd) of postmenopausal women.methods: studies were identified by searching electronic databases including cochrane library, medline, embase...
granymeh is a functional cytotoxic serine protease of nk cell granules,which expands the cell death-inducing repertoire of innate immune system.the purpose of this study was to determine granymeh(gzmh)level in breast cancer(bc) and healty women.this study was performed on 30 patients with bc and 30 healty woman.gzmh and estrogen levels were measured in cancer patients and healty women subseque...
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