Library organizations in the Netherlands show an increasing interest to employ depots for low-cost storage and demand fulfillment of item requests. Typically, all libraries organization have a shared catalog, and, on local unavailability, requests can be shipped from elsewhere organization. The depot used consolidate shipment by making tours along libraries, delivering requested items, but also...

Mathematical modeling of supply chain operations has proven to be one of the most complex tasks in the field of operations management and operations research. Despite the abundance of several modeling proposals in the literature; for vast majority of them, no effective universal application is conceived. This issue renders the proposed mathematical models inapplicable due largely to the fact th...

In this paper, a closed-loop location-inventory problem for spare parts is presented. The proposed supply chain network includes two echelons, namely (1) distribution centers (DCs) and repairing centers (RCs) and (2) operational bases. Multiple spare parts are distributed among operational bases from distribution centers in the forward supply chain and failed spare parts from operational bases ...

Motivation: An effective docking algorithm for antibody–protein antigen complex prediction is an important first step toward design of biologics and vaccines. We have recently developed a new class of knowledge-based interaction potentials called Decoys as the Reference State (DARS) and incorporated DARS into the docking program PIPER based on the fast Fourier transform correlation approach. Al...

Automated docking of drug-like molecules into receptors is an essential tool in structure-based drug design. While modeling receptor flexibility is important for correctly predicting ligand binding, it still remains challenging. This work focuses on an approach in which receptor flexibility is modeled by explicitly specifying a set of receptor side-chains a-priori. The challenges of this approa...