Identifying and interpreting pleiotropic loci is essential to understanding the shared etiology among diseases complex traits. A common approach mapping meta-analyze GWAS summary statistics across multiple However, this strategy does not account for genetic architectures of traits, such as correlations heritabilities. Furthermore, interpretation challenging because phenotypes often have differe...

A novel Monte Carlo method for linkage analyses involving large pedigrees and many polymorphic loci is introduced. Issues related to the efficiency of the method are discussed.

Molecular typing of Neisseria gonorrhoeae strains is an important tool for epidemiological studies of gonococcal infection and transmission. The recently developed multilocus sequence typing (MLST) method is based on the genetic variation among housekeeping genes. As a preliminary investigation for the development of such a method, we characterized the genetic diversity at 18 gonococcal houseke...

Genotyping for five short tandem repeat (STR) loci HUMvWA, HUMFES, HUMTPO, HUMTH01 and D3S1359 was done in 220 unrelated individuals from the population of Isfahan province of IR Iran. The loci were genotyped using the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE) and silver staining. The data demonstrated that the STR markers were all found informative i...

proliferation trend and polymorphism in 8 microsatellite dinucleotidalloci, a characteristic of japanese quail, were described in the present study. the primers concerned were tested in 200 birds from bonab research station. samples were taken from four strains of pharach, golden, tuxedo, and panda. in total, all loci were polymorphic, except for guj0001 and guj0041 in respective strains of pan...