Arm (A), leg (L) and combined arm and leg (A + L) ergometry modes were compared at power outputs of 49, 73.5 and 98 W. Selected cardiorespiratory variables and a rating of perceived exertion (RPE) were measured for 19 males of mean age 25.7 (+/- 5.5) years. Oxygen uptake (VO2), heart rate (HR), minute ventilation and rating of perceived exertion (RPE) were all higher (p less than 0.01) in A com...

BACKGROUND Midupper arm circumference (MUAC) has long been used in anthropometric assessments of nutritional status in field settings, especially in emergency situations, but percentile ranges for healthy, well-nourished children are currently unavailable. OBJECTIVE We developed reference curves for MUAC and derived measures of arm muscle area (AMA) and arm fat area (AFA) on the basis of the ...

Selenocysteine (Sec) is translationally incorporated into proteins in response to the UGA codon. The tRNA specific to Sec (tRNA(Sec)) is first ligated with serine by seryl-tRNA synthetase (SerRS). In the present study, we determined the 3.1 Å crystal structure of the tRNA(Sec) from the bacterium Aquifex aeolicus, in complex with the heterologous SerRS from the archaeon Methanopyrus kandleri. Th...

DNA aptamers are synthetic, single-stranded DNA oligonucleotides selected by SELEX methods for their binding with specific ligands. Here we present ethidium binding results for three related DNA aptamers (PDB code: 1OLD, 1DB6, and 2ARG)that bind L-argininamide (L-Arm). The ligand bound form of each aptamer's structure has been reported and each are found to be composed primarily of two domains ...

length from the proximal end. In salivary gland cells this chromosome consists of two euchromatic elements: a long distal one, and a short, proximal piece approximately l/20th as long. Both of these elements are connected with the nucleolus. It has also been proven that the nucleolus of the polytene X is located at a site corresponding to the secondary constriction of the metaphase chromosome, ...

This randomized phase II study evaluated two schedules of the marine compound Plitidepsin with or without co-administration of L-carnitine in patients with renal cell carcinoma. Patients had adequate performance status and organ function. The primary endpoint was the rate of disease control (no progression) at 12 weeks (RECIST). Other endpoints included the response rate and time dependent effi...