FRAX(®) is a computer-based algorithm developed by the World Health Organization Collaborating Centre for Metabolic Bone Diseases in Sheffield (UK). This algorithm calculates fracture probability from easily obtained clinical risk factors in men and women: age, sex, body mass index and dichotomized variables comprising prior fragility fracture, parental history of hip fracture, current tobacco ...

Concomitant traumatic brain injury (TBI) and long bone fracture are commonly observed in multitrauma and polytrauma. Despite clinical observations of enhanced bone healing in patients with TBI, the relationship between TBI and fracture healing remains poorly understood, with clinical data limited by the presence of several confounding variables. Here we developed a novel trauma model featuring ...

INTRODUCTION: One goal of reducing fracture risk is to maintain bone stiffness and strength with aging despite a net loss in bone mass. It is well recognized that age-related bone loss is often accompanied by continued periosteal apposition [1]. Because variation in the amount of periosteal expansion may be a major contributor to fracture risk [2], having a better understanding of the factors c...

BACKGROUND Osteoporosis in long bones involves loss of cortical thickness and of the trabecular microarchitecture. Deterioration and weakening of trabecular bone tissue during osteoporosis imposes greater physiological loads on the cortical shell. However, it is unclear whether trabecular bone significantly contributes to the strength of whole bones under non-physiological impact loads. METHO...

Non-insulin dependent diabetes mellitus (NIDDM) is most commonly current metabolic disorder as it affects more than 385 million and it is expected to reach about 590 million by 2035 worldwide [1], so that NIDDM has huge economic burden and adverse medical effects as there is a risk of fracture due to bone fragility in spite many researches confirm normal or even higher bone mineral density (BMD...

Healing of the bone is different with the other part of the body. Fracture healing is actually a bone regeneration with no scar tissues, where as in wound healing, injured tissue is replaced by  connective tissue which became a scar, Traditionally fracture healing is divided in to 4 stages: 1) Stage of inflammation; 2) Stage of soft callus; 3) Stage of hard callus and 4) Stage of remodeling. In...

Bisphosphonate excessively inhibits bone resorption and results in pathological fracture of the femur or ilium. The subject of this study was administered risedronate for 7 years; we suspected an easy fracture of the femoral diaphysis. In this study, we report the results of this patient's bone biopsy and bone morphometric analysis. A 76-year-old female patient presented with right femoral pain...

OBJECTIVES To retrospectively evaluate stabilisation of long-bone fractures in cats and small dogs using the Unilock system. METHODS Medical histories and radiographs of consecutive patients with long-bone fractures stabilised with the Unilock system were reviewed. Cases with follow-up radiographs taken at least four weeks postoperatively were included. Signalment of the patient, fracture loc...

Bisphosphonates (BPs) are the most widely used drugs to treat osteoporosis. However, recent reports associated to long-term BPs use with atypical low-impact fractures and prodromal pain. It is estimated that 26% of the cases of atypical fractures associated with the long-term use of BPs show delayed healing or nonunion. Teriparatide [PTH1-34] (TPTD) is an anabolic drug shown to be effective in ...

BACKGROUND Coaptive film (i.e., Steri-Strips™) is an adhesive tape used to replace sutures in wound closure. The use of coaptive film for wound closure after long bone fracture fixation has not been well documented in the literature. METHODS The aim of this prospective, randomized controlled trial comparing coaptive film with sutures for wound closure after long bone fracture fixation was ski...