Diabetes constitutes a major health challenge. Since cardiovascular complications are common in diabetic patients this will further increase the overall burden of disease. Furthermore, stress-induced hyperglycemia in non-diabetic patients with acute myocardial infarction is associated with higher in-hospital mortality. Previous studies implicate oxidative stress, excessive flux through the hexo...

The role of endogenous salicylic acid (SA) signalling cascades in plant responses to salt and oxidative stresses is unclear. Arabidopsis SA signalling mutants, namely npr1-5 (non-expresser of pathogenesis related gene1), which lacks NPR1-dependent SA signalling, and nudt7 (nudix hydrolase7), which has both constitutively expressed NPR1-dependent and NPR1-independent SA signalling pathways, were...

the semi-classical model of atom-field interaction has been fully studied for some multilevel atoms, e.g. vee, l, cascade x , y, and inverted y and so on. this issue is developed into the full-quantum electrodynamics formalism, where the probe and coupling electromagnetic fields are quantized. in this article, we investigate the full-quantum model of absorption and dispersion spectrum of trappe...

doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

drought is an important abiotic stress limiting plant performance. generation of reactive oxygen species (ros) is enhanced under stresses. two greenhouse experiments were conducted to evaluate the effect of phytohormones on the changes of antioxidant enzymes and carotenoids in petals of pot marigold (calendula officinalis l.) under drought stress. results showed that the activities of superoxid...

early life events influence life-long patterns of emotionality and stress responsiveness and alter the rate of brain and body aging.  much research attention has focused on the programming effects of the hypothalamus pituitary axis (hpa) in early life and on understanding hpa function in response to stressors in adulthood. in comparison, there has been relatively little research on adolescence,...

We addressed if oxidative stress in the renal cortex plays a role in the induction of hypertension and mitochondrial alterations in hyperuricemia. A second objective was to evaluate whether the long-term treatment with the antioxidant Tempol prevents renal oxidative stress, mitochondrial alterations, and systemic hypertension in this model. Long-term (11-12 weeks) and short-term (3 weeks) effec...

zno nps (zinc oxide nanoparticles) has generated significant scientific interest as a novel antibacterial and anticancer agent. since oxidative stress is a critical determinant of zno nps-induced damage, it is necessary to characterize their underlying mode of action. different structural and physicochemical properties of zno nps such as particle surface, size, shape, crystal structure, chemica...

Stress facilitates reinstatement of addictive drug seeking in animals and promotes relapse in humans. Acute stress has marked and long-lasting effects on plasticity at both inhibitory and excitatory synapses on dopamine neurons in the ventral tegmental area (VTA), a key region necessary for drug reinforcement. Stress blocks long-term potentiation at GABAergic synapses on dopamine neurons in the...

Stress has been shown to be associated with altered homeostasis that may lead to oxidant-antioxidant imbalance. Non-enzymatic antioxidants are important regulators of reactive oxygen species produced in extra-cellular milieu and represent the first line of defense against them. Extra-cellular non-enzymatic antioxidants may be disturbed by the production of superoxide and nitric oxide and this h...