This work evaluated the removal efficiency of 13 wastewater-borne pharmaceuticals in a pilot constructed wetland (CW) operated under different aeration strategies (no aeration, intermittent and continuous). Aeration improved conventional wastewater parameters targeted micropollutants, compared to non-aerated treatment. Reduction chemical oxygen demand (COD) total nitrogen (TN) was slightly high...

The occupancy by lorazepam of the benzodiazepine binding site of rat brain GABAA receptors was compared when measured using either in vivo binding of [H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) in terminal studies or [C]flumazenil binding in anesthetized animals assessed using a small animal positron emission tomography ...

Drug-assisted interviews are useful for psychiatric diagnosis and treatment. However, amobarbital, a typical medication used for this purpose, is associated with elevated risk of respiratory depression. Benzodiazepines are good substitutes for amobarbital, with similar therapeutic effects and fewer complications. Although drug-assisted interviews are not widely used, they may be beneficial for ...

graphical errors in our tables and in the labelling of Figure 3. Th ere have been no changes to the results or their interpretation. In Tables 1, 2 and 3 the number of dexmedetomidine patients without sepsis should read 21 instead of the published 20. Th e numbers in the corresponding text are correct. Th e corrected tables can be found overleaf. In Figure 3, in the “Patients at risk” table bel...

Structural or operational synchrony analysis with EEG was conducted in order to detect functional interaction between cortical areas during an enhanced inhibition induced by the GABAergic agonist lorazepam in a double-blind, randomized, placebo-controlled, cross-over study in eight healthy human subjects. Specifically, we investigated whether a neuronal inhibitory system in the brain mediates f...

A 65 year old man, with no past history of epilepsy or seizures and of weight 80kg, is admitted with sepsis. After a 5 minute generalized tonic-clonic seizure (GTCS) he is given 2mg of intravenous lorazepam. After multiple brief GTCS he is given a further 2 mg of intravenous lorazepam. He becomes obtunded. After a further 10 minutes when he has developed subtle left facial twitching, 1 g of phe...