Drug delivery for brain tumors is a questionable subject which is the major barrier in treatment. Nowadays, a lot of proposals have been developed to increase the amount of intravascular drug reaching the tumor. All drugs have a common disadvantage, only a small amount of delivered drug actually reaches the tumor. The systemic toxicity is the main doselimiting factor. When we are given directly...

A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of...

This paper integrates a cost reduction delivery policy into an imperfect production system with repairable items for the purpose of lowering producer’s stock holding cost. The present paper reexamines a manufacturing lot-size problem studied by a prior paper, and improves its production batch size solution in terms of lowering its inventory holding cost. An n+1 delivery policy is proposed here ...

Intraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug, or carrier solution. Because of the fast clearance of the conventional intravenous (IV) drug de...

Globalization has created tremendous opportunities, but also made business environment highly competitive and turbulent. To gain competitive advantage, management of present-day transnational firms always seeks options to trim down various transaction and coordination costs, especially in the area of controllable intra-supply chain system. This study investigates a multi-product intra-supply ch...

One aspect that has mostly been overlooked in traditional economic lot-sizing is the implication of decisions on manual tasks and workload. Although lot-sizing decisions can have a significant impact on required manual material handling and on human performance, works that consider ergonomic aspects in lot-sizing are rare. This paper presents a model that integrates ergonomic aspect in terms of...